Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Meloxicam
71125-38-7

Meloxicam synthesis

10synthesis methods
It can be synthesized in four steps from benzisothiazolo-3(2H)-one-1,1-dioxide. Reaction of benzothiazolo-3(2H)-one-1,1-dioxide with methyl chloroacetate gives the methyl 2(3H)-acetate derivative, which is isomerized with sodium methoxide in toluene-tert-butanol yielding methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide. Subsequent methylation with methyl iodide in methanol yields the 2-methyl compound. Finally this compound is treated with 2-amino-5-methylthiazole in xylene.
-

Yield:71125-38-7 98.5%

Reaction Conditions:

Stage #1: meloxicam potassium salt monohydratewith potassium hydroxide;pyrographite in ethanol;water at 40 - 45; for 0.666667 h;
Stage #2: with acetic acid in ethanol;water at 10 - 30; pH=3 - 5; for 2.5 h;Product distribution / selectivity;

Steps:

4

One proceeds according to Example 2 with the only difference that the solution of the potassium salt is treated with 6.0 ml 96% acetic acid instead of hydrochloric acid.

References:

WO2006/64298,2006,A1 Location in patent:Page 24

Meloxicam Related Search: