![](/CAS/GIF/36322-90-4.gif)
Piroxicam synthesis
- Product Name:Piroxicam
- CAS Number:36322-90-4
- Molecular formula:C15H13N3O4S
- Molecular Weight:331.35
![](https://www.chemicalbook.com/NewsImg/2021-01-25/20211251442357121.jpg)
An alternative way for making saccharin is from methyl ester o-aminobenzoic (anthranylic acid). This undergoes diazotization using nitrous acid, and the resulting diazonium salt (3.2.71) is reacted with sulfur dioxide in the presence of copper dichloride, forming the methyl ester o-sulfobenzoic acid (3.2.72). Reaction of the resulting product with chlorine gives o-chlorosulfonylbenzoic acid methyl ester (3.2.73), which upon reaction with ammonium gives o-sulfonylamidobenzoic acid methyl ester (3.2.74). In the presence of hydrogen chloride, the resulting product undergoes cyclization into saccharin (3.2.70).
![](https://www.chemicalbook.com/NewsImg/2021-01-25/202112514425312456.jpg)
![2-Aminopyridine](/CAS/GIF/504-29-0.gif)
504-29-0
540 suppliers
$5.00/5 g
![Piroxicam](/CAS/GIF/36322-90-4.gif)
36322-90-4
635 suppliers
$6.00/1g
Yield:-
Steps:
Multi-step reaction with 3 steps
1: CHCl3
2: 25 percent / sodium isopropoxide / propan-2-ol / 0.67 h / 140 °C
3: 210 mg / 0.94N NaOH / H2O; methanol / Ambient temperature
References:
Perillo;Schapira;Lamdan [Journal of Heterocyclic Chemistry,1983,vol. 20,# 1,p. 155 - 160]
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15448-99-4
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$26.00/250mg
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5221-37-4
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$37.00/250mg
![Piroxicam](/CAS/GIF/36322-90-4.gif)
36322-90-4
635 suppliers
$6.00/1g
![2-Aminopyridine](/CAS/GIF/504-29-0.gif)
504-29-0
540 suppliers
$5.00/5 g
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35511-15-0
170 suppliers
$75.00/5 g
![Piroxicam](/CAS/GIF/36322-90-4.gif)
36322-90-4
635 suppliers
$6.00/1g
![methyl 3-oxo1,2-benzisothiazole-2(3H)-acetate 1,1-dioxide](/CAS/GIF/6639-62-9.gif)
6639-62-9
38 suppliers
$65.00/10mg
![Piroxicam](/CAS/GIF/36322-90-4.gif)
36322-90-4
635 suppliers
$6.00/1g
![2-Aminopyridine](/CAS/GIF/504-29-0.gif)
504-29-0
540 suppliers
$5.00/5 g
![4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid isopropyl ester 1,1-dioxide](/CAS/GIF/118854-48-1.gif)
118854-48-1
87 suppliers
$180.00/10mg
![Piroxicam](/CAS/GIF/36322-90-4.gif)
36322-90-4
635 suppliers
$6.00/1g