Methyl 1-(3-broMophenyl)cyclopropane-1-carboxylate synthesis
- Product Name:Methyl 1-(3-broMophenyl)cyclopropane-1-carboxylate
- CAS Number:749928-59-4
- Molecular formula:C11H11BrO2
- Molecular Weight:255.11
124276-95-5
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74-88-4
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749928-59-4
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Yield:749928-59-4 64%
Reaction Conditions:
with potassium carbonate in acetonitrile at 50;
Steps:
INTERMEDIATE 36: methyl 1-(3-bromophenyl)cyclopropanecarboxylate
INTERMEDIATE 36: methyl 1-(3-bromophenyl)cyclopropanecarboxylate A mixture of 1-(3-bromophenyl)cyclopropanecarboxylic acid (250 mg, 1.037 mmol) and K2003 (717 mg, 5.18 mmol) in acetonitrile (10.3 ml) was treated with iodomethane (0.08 ml, 1.24 mmol) and the reaction mixture heated at 5000 overnight. The reaction mixture was filtered and the filtrate concentrated. The residue was partitioned between DCM (10 ml) and water (5 ml). The organic was collected via hydrophobic frit andconcentrated, the residue was placed under vacuum overnight to give the title compound (168 mg, 64 % yield). MS (mlz) 256.9 (M+2).
References:
WO2015/104684,2015,A1 Location in patent:Page/Page column 101; 102
106-93-4
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749928-59-4
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$55.00/250mg
1878-67-7
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749928-59-4
29 suppliers
$55.00/250mg