ChemicalBook CAS DataBase List METHYL 4-BROMO-3-METHOXYBENZOATE

METHYL 4-BROMO-3-METHOXYBENZOATE synthesis

9synthesis methods

Product Name:METHYL 4-BROMO-3-METHOXYBENZOATE
CAS Number:17100-63-9
Molecular formula:C9H9BrO3
Molecular Weight:245.07

106291-80-9
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77-78-1
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17100-63-9
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Yield:17100-63-9 99%

Reaction Conditions:

with potassium carbonate in acetone; for 3 h;Heating / reflux;

Steps:

35.B

Step B. Methyl 4-bromo-3-methoxybenzoate A solution of methyl 4-bromo-3-hydroxybenzoate of Step A (27 mmol), potassium carbonate (33 mmol), and dimethyl sulfate (32 mmol) in acetone (40 mL) was stirred at reflux temperature under nitrogen atmosphere for three hours. The mixture was cooled and 5 mL of water was added. The acetone was evaporated and 30 mL of water was added. The product was extracted into dichloromethane. The organic solution was dried over anhydrous magnesium sulfate, filtered and evaporated to give the title compound (6.5 g, 99%) as a hard, white crystalline solid.

References:

US2006/199806,2006,A1 Location in patent:Page/Page column 23

106291-80-9
176 suppliers
$8.00/250mg