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ChemicalBook CAS DataBase List Methyl 4-chloro-7-Methoxyquinoline-6-carboxylate

Methyl 4-chloro-7-Methoxyquinoline-6-carboxylate synthesis

6synthesis methods
205448-65-3 Synthesis
Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate

205448-65-3
158 suppliers
$13.00/100mg

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Yield:205448-66-4 94.53%

Reaction Conditions:

with trichlorophosphate in toluene at 25 - 95;

Steps:

1 Example 1: Preparation of Methyl 4-chloro-7-methoxyguinoline-6-carboxylate.
10.0 g of methyl 7-methoxy-4-oxo-1, 4-dthydroquinoline-6-carboxylate, 90 mL of toluene and 8.2 g of phosphoryl chloride were taken in a flask at 25-3OoC and heated to 90-95oC for 3-4 hours. The reaction was cooled to 25-3OoC and 100 mL of demineralized water was added to the above reaction mass. The organic layer was washed with 50 mL of demineralized water and to this 41 mL of 20% sodium hydroxide solution was added. The resulting compound was filtered, washed and dried under reduced pressure to obtain the title compound.Yield: 94.53 %; HPLC purity: 99.61%

References:

DR. REDDY'S LABORATORIES LIMITED;ARKALA, Anil Kumar Reddy;BHALERAO, Dinesh;MAHAPATRA, Tridib;MOVVA, Venkateswarlu;JINNA, Rajendar Reddy;ELATI, Raviram Chandrasekhar WO2019/92625, 2019, A1 Location in patent:Page/Page column 8; 9

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