Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate synthesis
- Product Name:Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
- CAS Number:205448-65-3
- Molecular formula:C12H11NO4
- Molecular Weight:233.22
![4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-2-methoxy-benzoic acid methyl ester](/CAS/20180703/GIF/205448-64-2.gif)
205448-64-2
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205448-65-3
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$13.00/100mg
Yield:205448-65-3 80.7%
Reaction Conditions:
in diphenylether;biphenyl at 170 - 185; for 0.75 h;Inert atmosphere;
Steps:
3
45 g (292 mmol) of biphenyl was weighed into a three-necked flask, 150 mL of diphenyl ether was added, the solvent was heated to 180 ° C under nitrogen atmosphere, and 18 g (53.7 mmol) of compound 4 was rapidly added under a nitrogen atmosphere, and a large amount of gas was released. The temperature was maintained at 170 to 185 ° C, and the reaction was continued for 45 minutes to stop the heating. Cooled to room temperature, a large amount of yellow solid precipitated, added petroleum ether, filtered, filter cakeThe crude product was washed well with diethyl ether.The crude product was purified by petrol-ethyl acetate (5:2 by volume), suction filtered and dried.A yellow solid (5) of 10.11 g was obtained in a yield of 80.7%.
References:
Nanjing Tian Yue Xing Biological Co., Ltd.;Wu Xueping;Chen Yao CN109456267, 2019, A Location in patent:Paragraph 0026; 0027
27492-84-8
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205448-65-3
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39106-79-1
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205448-65-3
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65-49-6
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205448-65-3
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$13.00/100mg