ChemicalBook CAS DataBase List Methyl 4-Methyl-5-oxopentanoate

Methyl 4-Methyl-5-oxopentanoate synthesis

11synthesis methods

Product Name:Methyl 4-Methyl-5-oxopentanoate
CAS Number:40630-06-6
Molecular formula:C7H12O3
Molecular Weight:144.17

3724-55-8 Synthesis

3724-55-8
90 suppliers
$106.00/1g

201230-82-2 Synthesis

201230-82-2
1 suppliers
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6654-36-0 Synthesis

6654-36-0
84 suppliers
$20.00/250mg

40630-06-6
8 suppliers
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Yield:-

Reaction Conditions:

with hydrogen;acetic acid;acetylacetonatodicarbonylrhodium(l);N-(6-diphenylphosphanylpyridin-2-ylcarbonyl)guanidine in tetrahydrofuran at 40; under 7500.75 Torr; for 4 h;Product distribution / selectivity;Autoclave;

Steps:

V.4.4.2
4. Hydroformylation of Methyl but-3-enoate (12) (Not According to the Invention)Reaction conditions: reactor: autoclave (A); molar ratio of [Rh(CO)₂acac]:(1):(12):CH₃COOH:standard=1:10:200:(as shown in Table 2): 100; solvent: THF (2 ml); starting concentration of the substrate (12): c₀(12)=0.2 M; synthesis gas: CO/H₂(1:1); reaction pressure: 10 bar; reaction temperature: 40° C.; reaction time: 4 h.Possible Products of the Hydroformylation: The turnover frequency (TOF; mol(aldehyde)/mol(catalyst) h^-1) was determined from the consumption of synthesis gas. The conversion (in %) and the regioselectivity of the reaction (molar ratio of (13)/(14)) was determined by integration of the characteristic signals of the reaction products formed in the ¹H-NMR spectrum of the resulting reaction mixture diluted with CDCl₃. Each experiment was repeated at least twice. By-products of this reaction were observed in an amount of <5% in all experiments.

References:

BASF SE US2010/240896, 2010, A1 Location in patent:Page/Page column 10-11