Methyl 5-formyl-2-methoxybenzoate synthesis
- Product Name:Methyl 5-formyl-2-methoxybenzoate
- CAS Number:78515-16-9
- Molecular formula:C10H10O4
- Molecular Weight:194.18
41489-76-3
137 suppliers
$8.00/1g
74-88-4
340 suppliers
$15.00/10g
78515-16-9
174 suppliers
$50.00/10g
Yield:78515-16-9 98%
Reaction Conditions:
Stage #1: methyl-5-formyl-2-hydroxybenzoatewith potassium carbonate in N,N-dimethyl-formamide at 80; for 0.5 h;
Stage #2: methyl iodide in N,N-dimethyl-formamide at 80; for 6 h;
Steps:
8.1 Step 1: Preparation of methyl 5-formyl-2-methoxybenzoate
Dissolve methyl 5-formyl-2-hydroxybenzoate (500.0 mg, 2.8 mmol) and potassium carbonate (1.2 g, 8.3 mmol) in DMF (10 mL), heat to 80 ° C for 0.5 hour, and then add methyl iodide (787.9 mg, 5.6 mmol) and maintained at 80 ° C for 6 hours. The reaction solution was cooled to room temperature, an appropriate amount of water was added, and extraction was performed 3 times with ethyl acetate. The organic phases were combined and washed with a saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated to give the title compound (530.0 mg, yield: 98%) in this step
References:
CN110724075,2020,A Location in patent:Paragraph 0283; 0284; 0285; 0286
75-75-2
611 suppliers
$10.00/5g
100-97-0
7 suppliers
$14.00/250G
606-45-1
248 suppliers
$9.00/10g
78515-16-9
174 suppliers
$50.00/10g
77802-37-0
3 suppliers
inquiry
78515-16-9
174 suppliers
$50.00/10g