Methyl 6-HydroxypyriMidine-4-carboxylate synthesis
- Product Name:Methyl 6-HydroxypyriMidine-4-carboxylate
- CAS Number:7399-93-1
- Molecular formula:C6H6N2O3
- Molecular Weight:154.12
67-56-1
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7399-93-1
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Yield:7399-93-1 70%
Reaction Conditions:
with chloro-trimethyl-silane at 20; for 8 h;
Steps:
33.2
Example 33.2Pyridazine-4-carboxylic acid ethyl ester To 6-pyrimidine-4-carboxylic acid (36.0 g, 257 mmol) in methanol (360 mL) was dropwise added chlorotrimethylsilane (56 g, 554 mmol) and then stirred for 8 hours at room temperature. The solvent was evaporated off and the solid was refluxed with 200 mL methanol for 30 minutes. The reaction mixture was cooled, the precipitated solid was filtered off and washed with a small amount of methanol and dried under vacuum at 35° C. to afford 27.9 g (70%) of the title compound.1H NMR (300 MHz, (CD3)2SO): δ (ppm) 12.50 (broad s, 1H), 8.23 (s, 1H), 6.83 (s, 1H), 3.80 (s, 3H).
References:
AstraZeneca AB;NPS PHARMACEUTICALS, INC. US2007/259862, 2007, A1 Location in patent:Page/Page column 40
67-56-1
737 suppliers
$7.29/5ml-f
6299-87-2
196 suppliers
$6.00/100mg
7399-93-1
83 suppliers
$31.00/250mg