ChemicalBook CAS DataBase List Methyl Mycophenolate (EP Impurity E)

Methyl Mycophenolate (EP Impurity E) synthesis

8synthesis methods

Product Name:Methyl Mycophenolate (EP Impurity E)
CAS Number:31858-66-9
Molecular formula:C18H22O6
Molecular Weight:334.36

67-56-1 Synthesis

67-56-1
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24280-93-1
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31858-66-9
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$75.00/5mg

Yield:31858-66-9 95.86%

Reaction Conditions:

with toluene-4-sulfonic acid for 2 h;Reflux;

Steps:

24.1 methyl (E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-isobenzofuran-5-yl)-4-methylhex-4-enoate

Compound 24A (1.5 g, 4.68 mmol) and p-toluenesulfonic acid(0.81 g, 4.70 mmol) dissolved in methanol (20 mL)Heat to reflux and stir for 2 h. The solvent was removed under reduced pressure.The residue was dissolved in ethyl acetate (50 mL)Wash with saturated sodium bicarbonate solution (50 mL x 3) and brine (50 mL x 1). The organic layer is dried and concentrated to give compound 24B. white solid (1.5 g, yield 95.86%).

References:

CN109305989,2019,A Location in patent:Paragraph 0676; 0679-0684

67-56-1 Synthesis

67-56-1
738 suppliers
$9.00/25ml