MK677 synthesis
- Product Name:MK677
- CAS Number:159634-87-4
- Molecular formula:C32H44N4O7S
- Molecular Weight:628.78
498-94-2
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Yield:-
Steps:
Multi-step reaction with 10 steps
1: 97 percent / K2CO3 / H2O / 58 h / 22 °C
2: (COCl)2 / toluene; dimethylformamide / 16 h / 18 °C
3: 94 percent / H2, DIEA, thioanisole / Pd/C / toluene / 22 h / 20 °C / 2068.6 Torr
4: 99 percent / TFA / CH2Cl2 / 17 h / 35 °C
5: NaBH4 / toluene / 0.5 h / -2 °C
6: DIEA / tetrahydrofuran / 2 h / 5 - 8 °C
7: 93 percent / H2 / Pd-C / ethanol / 5 h / 65 °C / 2068.6 Torr
8: DCC, HOBt / H2O; various solvent(s) / 5 h / Ambient temperature
9: MsOH / ethanol / 7.5 h / 35 - 40 °C
10: DCC, HOBt / various solvent(s) / 2 h / Ambient temperature
References:
Maligres, Peter E.;Houpis, Ioannis;Rossen, Kai;Molina, Audrey;Sager, Jess;Upadhyay, Veena;Wells, Kenneth M.;Reamer, Robert A.;Lynch, Joseph E.;Askin, David;Volante;Reider, Paul J.;Houghton, Peter [Tetrahedron,1997,vol. 53,# 32,p. 10983 - 10992]
138163-08-3
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184289-85-8
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184289-84-7
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159634-87-4
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