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ChemicalBook CAS DataBase List ML 161

ML 161 synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
2.1: 5%-palladium/activated carbon; hydrogen / methanol / 16 h
3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / Inert atmosphere; Cooling with ice
3.2: 18 h / Inert atmosphere

References:

Dockendorff, Chris;Aisiku, Omozuanvbo;Verplank, Lynn;Dilks, James R.;Smith, Daniel A.;Gunnink, Susanna F.;Dowal, Louisa;Negri, Joseph;Palmer, Michelle;MacPherson, Lawrence;Schreiber, Stuart L.;Flaumenhaft, Robert [ACS Medicinal Chemistry Letters,2012,vol. 3,# 3,p. 232 - 237]

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