MYCOPHENOLATE METHYL ESTER synthesis
- Product Name:MYCOPHENOLATE METHYL ESTER
- CAS Number:24243-40-1
- Molecular formula:C18H22O6
- Molecular Weight:334.36
67-56-1
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Yield:24243-40-1 91%
Reaction Conditions:
with thionyl chloride at 0 - 70;
Steps:
1 Compound 2 synthesis of
Weighing 5.0g compound 1, dissolved in 50 ml of in MeOH, 0 °C added dropwise under 4.0g (34.1mmol) SOCl 2, and then the reaction mixed solution in 70 °C lower stirring sleepovers, through the pressure-reducing process the solvent is evaporated, the residue through the 200 ml of DCM and 200 ml of NaHCO 3 for separating saturated aqueous solution, washing the organic phase with brine, then through Na 2 SO 4 dried, and concentrated and get 4.9g white solid compound 2, yield 91%.
References:
CN104597238,2016,B Location in patent:Paragraph 0070; 0071; 0072
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24243-40-1
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