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ChemicalBook CAS DataBase List N-(3,6-diMethylpyridin-2-yl)pivalaMide
1313762-34-3

N-(3,6-diMethylpyridin-2-yl)pivalaMide synthesis

3synthesis methods
-

Yield:1313762-34-3 74%

Reaction Conditions:

Stage #1: 2,2-dimethyl-N-(6-methylpyridin-2-yl)propanamidewith n-butyllithium in tetrahydrofuran;hexane at -78 - 0; for 1.5 h;Inert atmosphere;
Stage #2: methyl iodide in tetrahydrofuran;hexane at 0 - 20;Inert atmosphere;

References:

Vautravers, Nicolas R.;Regent, Damien D.;Breit, Bernhard [Chemical Communications,2011,vol. 47,# 23,p. 6635 - 6637] Location in patent:supporting information; experimental part