N-(5-bromopyridin-3-yl)-3-methylbutanamide synthesis
- Product Name:N-(5-bromopyridin-3-yl)-3-methylbutanamide
- CAS Number:1266227-13-7
- Molecular formula:C10H13BrN2O
- Molecular Weight:257.13
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Yield:1266227-13-7 74%
Reaction Conditions:
with triethylamine in dichloromethane at 0; for 0.5 h;
Steps:
2 Intermediate 2-2: R1a is i-Bu:
The raw material 2-1 (3.4 g, 20 mmol) was dissolved in dichloromethane, cooled to 0°C in an ice bath, and isovaleric acid chloride (1.5 eq) was dissolved in dichloromethane and added dropwise. Triethylamine (2 eq) was added. Stir under ice bath for 30 min. Spin dry, add ethyl acetate to dissolve, the organic layer is washed with dilute hydrochloric acid, Washed with saturated sodium bicarbonate, spin-dried, and slurried with dichloromethane to obtain 3.8 g of a white solid with a yield of 74%.
References:
WO2022/12058,2022,A1 Location in patent:Page/Page column 15-17
13535-01-8
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503-74-2
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1266227-13-7
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