![](/CAS/GIF/108-12-3.gif)
Isovaleryl chloride synthesis
- Product Name:Isovaleryl chloride
- CAS Number:108-12-3
- Molecular formula:C5H9ClO
- Molecular Weight:120.58
![Isovaleric acid](/CAS/GIF/503-74-2.gif)
503-74-2
401 suppliers
$5.00/10g
![Thionyl chloride](/CAS/GIF/7719-09-7.gif)
7719-09-7
391 suppliers
$15.00/10g
![Isovaleryl chloride](/CAS/GIF/108-12-3.gif)
108-12-3
180 suppliers
$10.00/1g
Yield:-
Reaction Conditions:
with N,N-dimethyl-formamide in tetrahydrofuran at 20; for 2 h;
Steps:
5.46 N-[5-({2-[(Cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-2,5-dimethyl-1,3-thiazole-4-carboxamide (29a)
General procedure: To a solution of 2,5-dimethyl-1,3-thiazole-4-carboxylic acid (107mg, 0.681mmol) in THF (5mL) was added thionyl chloride (118μL, 1.36mmol) and two drops of DMF. The mixture was stirred at room temperature for 2h and concentrated under reduced pressure. The residue was dissolved in DMA (6mL), and 27b (200mg, 0.619mmol) was added to the solution at 0°C. The mixture was stirred at room temperature for 2h. The mixture was diluted with saturated aqueous sodium hydrogen carbonate and extracted with AcOEt. The extract was washed with saturated aqueous sodium hydrogen carbonate, brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residual solid was recrystallized from EtOH to give 29a (248mg, 87%) as white crystals: mp 239-240°C; 1H NMR (DMSO-d6) δ 0.78-0.86 (4H, m), 2.04 (1H, br s), 2.23-2.28 (3H, m), 2.65 (3H, s), 2.70 (3H, s), 6.82 (1H, dd, J=8.3, 2.7Hz), 7.27 (1H, d, J=8.7Hz), 7.50 (1H, dd, J=9.5, 2.3Hz), 7.66 (1H, d, J=2.7Hz), 7.69-7.75 (1H, m), 8.82 (1H, dd, J=2.3, 0.8Hz), 9.66 (1H, s), 11.02 (1H, s); Anal. Calcd for C23H22N6O3S: C, 59.73; H, 4.79; N, 18.17. Found: C, 59.48; H, 4.80; N, 18.00.
References:
Oguro, Yuya;Cary, Douglas R.;Miyamoto, Naoki;Tawada, Michiko;Iwata, Hidehisa;Miki, Hiroshi;Hori, Akira;Imamura, Shinichi [Bioorganic and Medicinal Chemistry,2013,vol. 21,# 15,p. 4714 - 4729]
![Isovaleric acid](/CAS/GIF/503-74-2.gif)
503-74-2
401 suppliers
$5.00/10g
![Isovaleryl chloride](/CAS/GIF/108-12-3.gif)
108-12-3
180 suppliers
$10.00/1g
![Carbon tetrachloride](/CAS/GIF/56-23-5.gif)
56-23-5
6 suppliers
$18.50/48604
![Isovaleraldehyde](/CAS/GIF/590-86-3.gif)
590-86-3
355 suppliers
$10.00/5g
![Chloroform](/CAS/GIF/67-66-3.gif)
67-66-3
6 suppliers
$33.60/500ml
![Isovaleryl chloride](/CAS/GIF/108-12-3.gif)
108-12-3
180 suppliers
$10.00/1g
![Carbon tetrachloride](/CAS/GIF/56-23-5.gif)
56-23-5
6 suppliers
$18.50/48604
![Isovaleraldehyde](/CAS/GIF/590-86-3.gif)
590-86-3
355 suppliers
$10.00/5g
![Benzoyl peroxide](/CAS/GIF/94-36-0.gif)
94-36-0
482 suppliers
$20.60/1vl
![Chloroform](/CAS/GIF/67-66-3.gif)
67-66-3
6 suppliers
$33.60/500ml
![Isovaleryl chloride](/CAS/GIF/108-12-3.gif)
108-12-3
180 suppliers
$10.00/1g