![](/CAS/GIF/1690-75-1.gif)
N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER synthesis
- Product Name:N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER
- CAS Number:1690-75-1
- Molecular formula:C8H15NO2
- Molecular Weight:157.21
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
737 suppliers
$7.29/5ml-f
![Methyl isonipecotate](/CAS/GIF/2971-79-1.gif)
2971-79-1
281 suppliers
$10.00/10g
![N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER](/CAS/GIF/1690-75-1.gif)
1690-75-1
163 suppliers
$8.00/5g
Yield:1690-75-1 91%
Reaction Conditions:
with formaldehyd;formic acid in water for 3 h;Heating / reflux;
Steps:
To a stirred solution of methyl isonipecotate (L. OOG, 7.00 mmol) in methanol (25 ml) was added formic acid (5.52g, 12.00 mmol) and a solution of formaldehyde (2.67g, 35.00 mmol, 40% aqueous) and the reaction heated at reflux. After 3 hours the reaction was cooled and concentrated under reduced pressure. The aqueous solution was basified with NAHC03 and extracted with DCM (3 x 30 ml), dried (MGSO4) and concentrated under reduced pressure to give a brown liquid (L. OOG, 910-.) ; b (270 MHz; CDC13 ; Me4Si), 1.69-2. 03 (6 H, m), 2.23-2. 32 (4H, m), 2.78- 2.83 (2H, m), 3.68 (3 H, s); M/Z (APCI) 158 (100% [M+H] +), 126 (33, C7H120N).
References:
BIOFOCUS PLC WO2004/58259, 2004, A1 Location in patent:Page/Page column 26-27
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
737 suppliers
$7.29/5ml-f
![1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE](/CAS/GIF/71985-80-3.gif)
71985-80-3
151 suppliers
$6.00/1g
![N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER](/CAS/GIF/1690-75-1.gif)
1690-75-1
163 suppliers
$8.00/5g
![1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE](/CAS/GIF/71985-80-3.gif)
71985-80-3
151 suppliers
$6.00/1g
![N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER](/CAS/GIF/1690-75-1.gif)
1690-75-1
163 suppliers
$8.00/5g
![Methyl isonipecotate](/CAS/GIF/2971-79-1.gif)
2971-79-1
281 suppliers
$10.00/10g
![N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER](/CAS/GIF/1690-75-1.gif)
1690-75-1
163 suppliers
$8.00/5g
![Pyridinium, 4-(methoxycarbonyl)-1-methyl-, iodide (1:1)](/CAS/20211123/GIF/7630-02-6.gif)
7630-02-6
7 suppliers
inquiry
![N-METHYL-4-PIPERIDINECARBOXYLIC ACID METHYL ESTER](/CAS/GIF/1690-75-1.gif)
1690-75-1
163 suppliers
$8.00/5g