ChemicalBook CAS DataBase List 4-Chloro-N-methylpiperidine

4-Chloro-N-methylpiperidine synthesis

6synthesis methods

Product Name:4-Chloro-N-methylpiperidine
CAS Number:5570-77-4
Molecular formula:C6H12ClN
Molecular Weight:133.62

106-52-5 Synthesis

106-52-5
355 suppliers
$6.00/25g

5570-77-4
354 suppliers
$14.00/5g

Yield:5570-77-4 80%

Reaction Conditions:

with thionyl chloride;triethylamine in dichloromethane at 20 - 40; for 2 h;

Steps:

4.1 Synthesis of N-methylpiperidine-4-boronic acid
The first step: in the reaction flask, N-methylpiperidin-4-ol (115.2g, 1mol),Dissolve triethylamine (506.0g, 5mol) in dichloromethane (955.0g), stir well, control the temperature from 20°C to 40°C ,Thionyl chloride (234.9g, 2mol) was added dropwise, after the dropwise addition, the reaction was stirred at 40°C for 2 hours,After the reaction is detected by GC, add water (1000.0g) to quench the reaction,The water layer was extracted twice with dichloromethane (250.0g*2 times), the organic layers were combined, and the organic solvent was evaporated to dryness first.Then use an oil pump to distill 106.9g of light yellow liquid product N-methylpiperidine-4-chloride under reduced pressure.HPLC purity>98%, yield 80%.

References:

Dalian Shuangpeng Pharmaceutical And Chemical Co., Ltd.;Sun Fuyuan;Zheng Peng CN111171063, 2020, A Location in patent:Paragraph 0027

FullText