![](/CAS/GIF/106-52-5.gif)
N-Methyl-4-piperidinol synthesis
- Product Name:N-Methyl-4-piperidinol
- CAS Number:106-52-5
- Molecular formula:C6H13NO
- Molecular Weight:115.17
Yield:106-52-5 89%
Reaction Conditions:
with hydrogenchloride;palladium 10% on activated carbon;hydrogen in methanol;water; pH=2 - 3;
Steps:
1.1 Step 1) 1-methyl-4-piperidinol
A mixture of 4-piperidinol (1.16g, 10.07mmol) and 47% aqueous formaldehyde solution (10 mL) were dissolved in methanol (10 mL), and acidified with concentrated hydrochloricTo pH 2-3, to the system was added 10% Pd / C (300mg), two days the reaction system was kept under a hydrogen atmosphere. Completion of the reaction, filtered and the filtrate reducedPressure concentrated and the crude product purified by column chromatography (MeOH) to give a white solid (1.59g, 89%)
References:
CN105367582,2016,A Location in patent:Paragraph 0253; 0254; 0255
![1-Methyl-4-piperidone](/CAS/GIF/1445-73-4.gif)
1445-73-4
466 suppliers
$15.00/25g
![N-Methyl-4-piperidinol](/CAS/GIF/106-52-5.gif)
106-52-5
358 suppliers
$6.00/25g
![1-Methyl-4(1H)-pyridinone](/CAS/GIF/695-19-2.gif)
695-19-2
11 suppliers
$305.00/500mg
![N-Methyl-4-piperidinol](/CAS/GIF/106-52-5.gif)
106-52-5
358 suppliers
$6.00/25g
![1-Methyl-4-piperidone](/CAS/GIF/1445-73-4.gif)
1445-73-4
466 suppliers
$15.00/25g
![Aniline](/CAS/GIF/62-53-3.gif)
62-53-3
635 suppliers
$10.00/1g
![N-Methyl-4-piperidinol](/CAS/GIF/106-52-5.gif)
106-52-5
358 suppliers
$6.00/25g
![N-(1-METHYLPIPERIDIN-4-YL)ANILINE](/CAS/GIF/22261-94-5.gif)
22261-94-5
29 suppliers
$34.79/1g
![1-Methyl-4-piperidinol hydrochloride](/CAS/GIF/34737-83-2.gif)
34737-83-2
35 suppliers
inquiry
![N-Methyl-4-piperidinol](/CAS/GIF/106-52-5.gif)
106-52-5
358 suppliers
$6.00/25g