Noopept synthesis

2synthesis methods

Product Name:Noopept
CAS Number:157115-85-0
Molecular formula:C17H22N2O4
Molecular Weight:318.37

Noopept (ethyl ester of N-phenylacetyl-L-prolylglycine) was designed as a drug at State Zakusov Institute of Pharmacology. The synthesis of the drug is based on the original hypothesis of peptide design, according to which structures similar to known psychotropic agents are reproduced using appropriate amino acids. The non-peptide prototype of Noopept is the nootropic drug Piracetam.
Synthesis of Noopept

1. Perform the carboxylation of N-phenylacetyl-L-proline and ethyl glycine in the presence of isobutyl chloroformate.
2. Add slowly isobutyl chloroformate (1.17 g, 8.6 mmol) to a solution of N-phenylacetyl-L-proline (2.0 g, 8.6 mmol) dissolved in a mixed solvent of THF and dichloromethane (1:1; THF/dichloromethane (v/v)).3.Stir the mixture for 4 h at 0 ～5 °C
Molecular Mechanism Underlying the Action of Substituted Pro-Gly Dipeptide Noopept

(S)-1-(2-phenylacetyl)pyrrolidine-2-carboxylic acid

2752-38-7
21 suppliers
$237.00/500mg

157115-85-0
361 suppliers
$5.00/100mg

Yield:-

Steps:

Multi-step reaction with 2 steps
1: N-methylmorpholine / CHCl₃ / 0.03 h / -10 °C
2: N-methylmorpholine / CHCl₃; dimethylformamide / 1.5 h / -5 - 20 °C

References:

Gudasheva;Voronina;Ostrovskaya;Rozantsev;Vasilevich;Trofimov;Kravchenko;Skoldinov;Seredenin [European Journal of Medicinal Chemistry,1996,vol. 31,# 2,p. 151 - 157]

147-85-3 Synthesis

147-85-3
1007 suppliers
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157115-85-0
361 suppliers
$5.00/100mg

References

Noopept Related Search:

Donepezil Minoxidil Aniline Pterostilbene Glycine ethyl ester hydrochloride GW9508 Choline glycerophosphate