ChemicalBook CAS DataBase List phthalonic acid

phthalonic acid synthesis

14synthesis methods

Product Name:phthalonic acid
CAS Number:528-46-1
Molecular formula:C9H6O5
Molecular Weight:194.14

91-20-3 Synthesis

91-20-3
491 suppliers
$13.19/250mg

528-46-1
25 suppliers
$305.00/250mg

Yield: 45.3%

Reaction Conditions:

with potassium permanganate;sodium hydroxide in water at 100;

Steps:

5.1.11 Preparation of 2-carboxyethl formyl benzoic acid (11)
Potassium permanganate (132.5g, 0.84mol) in H₂O (937.0mL) was added drop-wise to the vigorously stirred liquated solution of naphthalene (20.0g, 0.16mol) in sodium hydroxide solution (312.0mL, 0.5mol). After completion of reaction as indicated by TLC, ethanol (30.0mL) was added and stirred for another 15min. The mixture was then cooled and filtered, and the filtrate was acidified by concentrated hydrochloric acid (93.8mL) and evaporated to dryness to give the compound 11 as a white solid (14.2g, 45.3%). MS (ESI) m/z: 195.1 [M+H]⁺

References:

Zhao, Sijia;Zhang, Yu;Zhou, Hongyang;Xi, Shuancheng;Zou, Bin;Bao, Guanglong;Wang, Limei;Wang, Jiao;Zeng, Tianfang;Gong, Ping;Zhai, Xin [European Journal of Medicinal Chemistry,2016,vol. 120,p. 37 - 50]

201230-82-2 Synthesis