Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook

Welcome back!

Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List PLERIXAFOR

PLERIXAFOR synthesis

5synthesis methods
Plerixafor can be synthesized by several related procedures starting from tetraazacyclotetradecane, the macrocyclic tetraamine cyclam. The general synthetic strategy entails the masking of three of the four ring nitrogens, followed by alkylation with para-xylylene dibromide, and subsequent removal of the masking groups. In one approach, tetraazacyclotetradecane is protected as the phosphorotriamide derivative by reaction with tris (dimethylamino)phosphine followed by oxidation with carbon tetrachloride and sodium hydroxide. After condensation with xylylene dibromide, the dimeric bis-phosphoramide intermediate is hydrolyzed to plerixafor by treatment with dilute hydrochloric acid solution.
623-24-5 Synthesis
alpha,alpha'-Dibromo-p-xylene

623-24-5
315 suppliers
$6.00/1g

PLERIXAFOR

110078-46-1
258 suppliers
$19.00/5mg

-
1-(4,8-bis-(2,2,2-trifluoroacetyl)-11-{4-[4,8,11-tris-(2,2,2-trifluoroacetyl)-1,4,8,11-tetraazacyclotetradec-1-ylMethyl]-benzyl}-1,4,8,11-tetraazacyclotetradec-1-yl)-2,2,2-trifluoroethanone

406939-93-3
14 suppliers
$160.00/2.5mg

PLERIXAFOR

110078-46-1
258 suppliers
$19.00/5mg

References
592516-98-8

592516-98-8
1 suppliers
inquiry

PLERIXAFOR

110078-46-1
258 suppliers
$19.00/5mg

References
623-24-5 Synthesis
alpha,alpha'-Dibromo-p-xylene

623-24-5
315 suppliers
$6.00/1g

295-37-4 Synthesis
1,4,8,11-TETRAAZACYCLOTETRADECANE

295-37-4
301 suppliers
$18.00/250mg

PLERIXAFOR

110078-46-1
258 suppliers
$19.00/5mg

References
1,4,8,11-Tetraazacyclotetradecane-1,4,8-tricarboxylic acid, 11,11'-[1,4-phenylenebis(methylene)]bis-, hexakis(1,1-dimethylethyl) ester (9CI)

175854-48-5
1 suppliers
inquiry

PLERIXAFOR

110078-46-1
258 suppliers
$19.00/5mg

References

PLERIXAFOR Related Search:

Varenicline tartrate GSK-3BETA INHIBITOR XII Enzalutamide Gefitinib Nintedanib esylate Alectinib Hydrochloride 1,4,8,11-TETRAAZACYCLOTETRADECANE