Pyridine-2-carbaldehyde ethylene acetal synthesis

4synthesis methods

Product Name:Pyridine-2-carbaldehyde ethylene acetal
CAS Number:5693-54-9
Molecular formula:C8H9NO2
Molecular Weight:151.16

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Yield:5693-54-9 475 g (67%)

Reaction Conditions:

with p-toluenesulfonic acid monohydrate in ethylene glycol;toluene;

Steps:

1.b (b)

(b) A mixture of 2-pyridinecarboxaldehyde (500 g, 4.67 mol), 561 mL of ethylene glycol, and 234 g of p-toluenesulfonic acid monohydrate in 5.8 L of toluene was heated to reflux while distilling (azeotropic) water formed during the reaction. The solvent was removed in vacuo and the residue was distilled to afford 475 g (67%) of 2-(1,3-dioxolan-2-yl)pyridine (Formula V: R¹ =H).

References:

US5554620,1996,A

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107-21-1 Synthesis