Pyridine, 3-chloro-2-(chloromethyl)- (9CI) synthesis
- Product Name:Pyridine, 3-chloro-2-(chloromethyl)- (9CI)
- CAS Number:185315-53-1
- Molecular formula:C6H5Cl2N
- Molecular Weight:162.02
60588-81-0
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185315-53-1
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$61.00/100mg
Yield:185315-53-1 69%
Reaction Conditions:
with methanesulfonyl chloride;N-ethyl-N,N-diisopropylamine in dichloromethane at 0 - 20; for 3 h;
Steps:
Synthesis of 3-chloro-2-(chloromethvDpyridine (32)
Synthesis of 3-chloro-2-(chloromethvDpyridine (32 31 To a solution of compound 31 (300 mg, 2.1 mmol) in DCM (4 mL) was added DIE A (539 mg, 4.2 mmol) at 0 °C, then MsCl (263 mg, 2.3 mmol) was added dropwise at 0 °C. The mixture was stirred at room temperature for 3h. Water was added, and the mixture was extracted with DCM, washed with sat. NaHCO and brine, dried over a?.S04, filtered, concentrated under reduced pressure to give compound 32 (240 mg, 69 %) as a yellow oil.
References:
WO2015/143164,2015,A1 Location in patent:Page/Page column 119-120
52313-57-2
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185315-53-1
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124425-86-1
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185315-53-1
40 suppliers
$61.00/100mg