ChemicalBook CAS DataBase List (R)-1-Boc-3-methylpiperazine

(R)-1-Boc-3-methylpiperazine synthesis

3synthesis methods

Product Name:(R)-1-Boc-3-methylpiperazine
CAS Number:163765-44-4
Molecular formula:C10H20N2O2
Molecular Weight:200.28

To a solution of (R)-methylpiperazine (400 mg) in dichloromethane (20 mL) at 0 ℃ was added di-tert-butyl dicarbonate (871 mg). The reaction was stirred at room temperature for 4 h and then quenched with water (20 mL), followed by extraction into dichloromethane (2 x 40 mL). The combined organics were washed with saturated aqueous brine solution (40 mL), dried (MgSO4), and concentrated to give (R)-1-Boc-3-methylpiperazine as a white solid (669 mg, 84%).

(R)-4-Boc-2-methylpiperazine

24424-99-5 Synthesis

24424-99-5
836 suppliers
$13.50/25G

75336-86-6 Synthesis

75336-86-6
236 suppliers
$9.00/5g

163765-44-4
265 suppliers
$6.00/1g

Yield:163765-44-4 84%

Reaction Conditions:

in dichloromethane at 0 - 20; for 4 h;

Steps:

195
To a solution of (R)-methylpiperazine (400 mg) in dichloromethane (20 mL) at 0 ⁰C was added di-tert-butyl dicarbonate (871 mg). The reaction was stirred at room temperature for 4 h and then quenched with water (20 mL) and extracted into dichloromethane (2 x 40 mL). The combined organics were washed with saturated aqueous brine solution (40 mL), dried (MgSO₄) and concentrated to give (R)-3-methyl-piperazine-l- carboxylic acid tert-butyl ester as a white solid (669 mg, 84%).

References:

PIRAMED LIMITED;GENENTECH, INC.;BAYLISS, Tracy;CHUCKOWREE, Irina;FOLKES, Adrian;OXENFORD, Sally;WAN, Nan, Chi;CASTANEDO, Georgette;GOLDSMITH, Richard;GUNZNER, Janet;HEFFRON, Tim;MATHIEU, Simon;OLIVERO, Alan;STABEN, Steven;SUTHERLIN, Daniel, P.;ZHU, Bing-Yan WO2008/70740, 2008, A1 Location in patent:Page/Page column 191

FullText

75336-86-6 Synthesis

75336-86-6
236 suppliers
$9.00/5g

163765-44-4
265 suppliers
$6.00/1g

References

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

58632-95-4
266 suppliers
$7.00/5g

75336-86-6 Synthesis

75336-86-6
236 suppliers
$9.00/5g

163765-44-4
265 suppliers
$6.00/1g

References

(R)-1-Boc-3-methylpiperazine Related Search:

tert-Butyldimethylsilyl chloride 1-BENZHYDRYLPIPERAZINE Methyl salicylate Levodropropizine 1-Methylpiperazine tert-Butanol 1,2-Dimethylhydrazine Dihydrochloride 2-Methylpiperazine Methylparaben (S)-4-N-BOC-PIPERAZINE-2-CARBOXYLIC ACID