![](/CAS/GIF/10420-89-0.gif)
(S)-(-)-1-(1-Naphthyl)ethylamine synthesis
- Product Name:(S)-(-)-1-(1-Naphthyl)ethylamine
- CAS Number:10420-89-0
- Molecular formula:C12H13N
- Molecular Weight:171.24
![1-Naphthalenemethanol, α-methyl-, 1-methanesulfonate, (αR)-](/CAS/20210305/GIF/1025949-34-1.gif)
1025949-34-1
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![(S)-(-)-1-(1-Naphthyl)ethylamine](/CAS/GIF/10420-89-0.gif)
10420-89-0
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Yield:94 % ee
Reaction Conditions:
with ammonia in toluene at 87; under 2250.23 Torr; for 5 h;
Steps:
4
Aqueous ammonia (30%, 27.7 ml) was added to a Parr reactor. The toluene solution of the product of stage 3 was added and the reactor was sealed and heated to 87°C at 3 bar and allowed to react for 5 hours. At the end of this time the pressure was released and the toluene solution was separated and then evaporated to dryness to yield the title product, (S)-l-naphthylethylamine, in 94% e.e. (S)-l-naphthylethylamine was assessed using the HPLC protocol as described in stage 1(a) where (S)-1-Naphthylethylamine eluted at 12.0 minutes and (R)-l-Naphthylethylamine eluted at 5.9 minutes.
References:
WO2004/110976,2004,A2 Location in patent:Page/Page column 22
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![(S)-(-)-1-(1-Naphthyl)ethylamine](/CAS/GIF/10420-89-0.gif)
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$6.00/1g
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