Tadalafil synthesis
- Product Name:Tadalafil
- CAS Number:171596-29-5
- Molecular formula:C22H19N3O4
- Molecular Weight:389.4
74-89-5
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171489-59-1
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$7.00/1g
171596-29-5
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$10.00/1g
Yield:171596-29-5 95.3%
Reaction Conditions:
in methanol; for 3 h;Reflux;Large scale;
Steps:
20-21 Synthesis of Tadalafil
Add Intermediate 3 (20kg, 47mol), 30% methylamine methanol solution (25kg, 235mol), 140L of methanol was added to the reactor, Heat and stir to reflux, keep the reaction for 3h, After the reaction was detected by HPLC, it was cooled down to room temperature, centrifuged and washed with a small amount of methanol. The product was dried to obtain 17.3 kg of a white solid with a yield of 95.3% and a purity of 99.3%.
References:
CN110437228,2019,A Location in patent:Paragraph 0083-0088
120-57-0
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