Tapinarof synthesis
- Product Name:Tapinarof
- CAS Number:79338-84-4
- Molecular formula:C17H18O2
- Molecular Weight:254.32
141509-20-8
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Yield:79338-84-4 85%
Reaction Conditions:
with pyridine hydrochloride in toluene at 90 - 180; for 2.5 h;Inert atmosphere;Large scale;
Steps:
3 Example 3 Preparation of phenenmod
Add 36kg of pyridine hydrochloride into the 100L reactor, under the protection of nitrogen, heat up to 90, add 10kg of E-4-isopropyl-3,5-dimethoxy-stilbene, and heat up to 180 or above and stir to react. About 2.5h, cool to about 90°C, add 50L of toluene, stir and cool, and filter the precipitated pyridine hydrochloride. The filtrate was washed twice with 5L of 1mol/L dilute hydrochloric acid, added with 1kg of activated carbon, heated and stirred for 0.5h, filtered, and concentrated to obtain a crude product.Recrystallization of n-heptane yields 7.6 kg of solid, with a yield of 85%.
References:
CN112661611,2021,A Location in patent:Paragraph 0029
115781-08-3
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