ChemicalBook CAS DataBase List tert-butyl 4-(bromomethyl)-1H-indole-1-carboxylate

tert-butyl 4-(bromomethyl)-1H-indole-1-carboxylate synthesis

8synthesis methods

Product Name:tert-butyl 4-(bromomethyl)-1H-indole-1-carboxylate
CAS Number:220499-13-8
Molecular formula:C14H16BrNO2
Molecular Weight:310.19

59382-59-1
253 suppliers
$15.00/5g

tert-butyl 4-(bromomethyl)-1H-indole-1-carboxylate

220499-13-8
25 suppliers
$295.00/250MG

Yield:-

Steps:

Multi-step reaction with 5 steps
1: dimethylformamide / 12 h / 120 °C
2: H₂ / 10 percent Pd/C / benzene / 12 h / 2844.31 Torr / Ambient temperature
3: 100 percent / DMAP / acetonitrile / 12 h / Ambient temperature
4: 88 percent / DIBAL / diethyl ether; CH₂Cl₂ / 0.5 h / -78 °C
5: 84 percent / PBr₃ / diethyl ether; CH₂Cl₂ / 0.5 h / 0 °C

References:

Fauq, Abdul H.;Hong, Feng;Cusack, Bernadette;Tyler, Beth M.;Ping-Pang, Yuan;Richelson, Elliott [Tetrahedron Asymmetry,1998,vol. 9,# 23,p. 4127 - 4134]