ChemicalBook CAS DataBase List TETRAETHYLENEGLYCOL MONOMETHYL ETHER

TETRAETHYLENEGLYCOL MONOMETHYL ETHER synthesis

8synthesis methods

Product Name:TETRAETHYLENEGLYCOL MONOMETHYL ETHER
CAS Number:23783-42-8
Molecular formula:C9H20O5
Molecular Weight:208.25

2H-Pyran, tetrahydro-2-(3,6,9,12-tetraoxatridec-1-yloxy)-

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Yield:23783-42-8 90%

Reaction Conditions:

with pyridinium p-toluenesulfonate in methanol at 0 - 20; for 16 h;

Steps:

5.B 2,5,8,1 1-Tetraoxatridecan- 13-ol (5-2A)
To a solution of 2-(2,5,8,l l-tetraoxatridecan-13-yloxy)tetrahydro-2H-pyran 5-lA (280 mg, 0.96 mmol) in MeOH (5 mL) was added PPTS (24 mg, 0.096 mmol) and stirred at 0 °C to RT for 16 hr. The reaction mixture was concentrated under reduced pressure to get crude compound. Obtained crude was purified using silica gel column chromatography 5% MeOH in DCM to afford 5-2A (180 mg, 0.87 mmol, 90% yield) as a pale yellow liquid

References:

COCRYSTAL PHARMA, INC.;JACOBSON, Irina C.;FEESE, Michael D.;LEE, Sam S. WO2016/154241, 2016, A1 Location in patent:Paragraph 328; 331

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