ChemicalBook CAS DataBase List 3-Furancarboxamide, tetrahydro-

3-Furancarboxamide, tetrahydro- synthesis

5synthesis methods

Product Name:3-Furancarboxamide, tetrahydro-
CAS Number:871677-92-8
Molecular formula:C5H9NO2
Molecular Weight:115.13

53662-85-4 Synthesis

53662-85-4
75 suppliers
$5.00/100mg

871677-92-8
30 suppliers
$90.00/100mg

Yield:871677-92-8 100%

Reaction Conditions:

with ammonia in methanol at 80; for 72 h;

Steps:

Intermediate 4

To a solution of methyl tetrahydrofuran-3-carboxylate (15 g) in ammonia (7 N solution in MeOH, 110 mL) was heated to 80° C. for 72 h.
The reaction mixture was then concentrated and dried under high vacuum to afford tetrahydrofuran-3-carboxamide (15 g, quantitative yield) as an off-white solid. ¹H NMR (400 MHz, DMSO-d) δ ppm 7.38 (brs, 1H), 6.87 (brs, 1H), 3.84 (t, J=8.0 Hz, 1H), 3.72-3.62 (m, 3H), 2.92 (m, 1H), 1.98 (m, 2H).

References:

US2018/201610,2018,A1 Location in patent:Paragraph 0076; 0078

89364-31-8 Synthesis