![](/CAS/GIF/68786-66-3.gif)
Triclabendazole synthesis
- Product Name:Triclabendazole
- CAS Number:68786-66-3
- Molecular formula:C14H9Cl3N2OS
- Molecular Weight:359.66
Iddon, Brian; Kutschy, Peter; Robinson, Andrew G.; Suschitzky, Hans; Kramer, Walter; Neugebauer, Franz A. 2H-Benzimidazoles (isobenzimidazoles). Part 7. A new route to triclabendazole [5-chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole] and congeneric benzimidazoles. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), Issue 22, Pages 3129-34, 1992.
![5-chloro-6-(2,3-dichorophenoxy)-2-thio-1H-benzimidazole](/CAS/20180703/GIF/68828-69-3.gif)
68828-69-3
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68786-66-3
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$5.00/100mg
Yield:68786-66-3 94%
Reaction Conditions:
with potassium hydroxide in ethanol;water at 10 - 50; for 20 h;
Steps:
1.5 (5) Preparation of 5-chloro-6-(2,3-dichlorophenoxy)-2-methylmercaptobenzimidazole
A solution of 5-chloro-6-(2,3-dichlorophenoxy)-1H-benzimidazol-2(3H)-thione (4 g, 11.6 mmol)Dissolved in K0H (1.75g) ethanol: water (2: 1, V / V) solution,10 ~ 15 ° CCH3 I (1.67 g, 11.6 mmol) was added over 30 min,Was added dropwise to the above solution.After dripping at room temperature for 30min, then at 50 ° C for 1 h, room temperature and stirring for 18h.The resulting emulsion was slowly poured into water (50 ml) at 30 m and stirred to form a precipitate.Filtered, washed with water (30 ml) and dried in vacuo at 50 ° C to give the product 4 g, recrystallized from an ethanol-water solution,A white crystalline powder product (3.798, yield 94%) was obtained
References:
Hangzhou Hongqiao Biological Co., Ltd.;Zhejiang Sci-Tech University;Shu Jianhong;Yang Fang;Jin Jia;Zhang Yu;Wang Han;Zhou Quanli CN106632067, 2017, A Location in patent:Paragraph 0016; 0020
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77-78-1
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68786-66-3
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![5-chloro-6-(2,3-dichorophenoxy)-2-thio-1H-benzimidazole](/CAS/20180703/GIF/68828-69-3.gif)
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![Triclabendazole](/CAS/GIF/68786-66-3.gif)
68786-66-3
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![2,3-Dichlorophenol](/CAS/GIF/576-24-9.gif)
576-24-9
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68786-66-3
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![Triclabendazole](/CAS/GIF/68786-66-3.gif)
68786-66-3
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$5.00/100mg