ChemicalBook CAS DataBase List UNC-0642

UNC-0642 synthesis

7synthesis methods

Product Name:UNC-0642
CAS Number:1481677-78-4
Molecular formula:C29H44F2N6O2
Molecular Weight:546.7

3943-74-6 Synthesis

3943-74-6
338 suppliers
$5.00/100mg

1481677-78-4
73 suppliers
$36.00/1mg

Yield:-

Steps:

Multi-step reaction with 8 steps
1.1: potassium carbonate / acetonitrile / Reflux
2.1: nitric acid; acetic anhydride / 0 - 20 °C
3.1: potassium carbonate; sodium iodide; tetra-(n-butyl)ammonium iodide / acetonitrile / Reflux
4.1: iron; ammonium acetate / ethyl acetate; water / Reflux
5.1: acetic acid / water / 20 °C
5.2: Reflux
6.1: trichlorophosphate / N,N-dimethyl-aniline / Reflux
7.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C
8.1: trifluoroacetic acid / isopropyl alcohol / 0.25 h / 160 °C / Microwave irradiation; Sealed tube

References:

Liu, Feng;Barsyte-Lovejoy, Dalia;Li, Fengling;Xiong, Yan;Korboukh, Victoria;Huang, Xi-Ping;Allali-Hassani, Abdellah;Janzen, William P.;Roth, Bryan L.;Frye, Stephen V.;Arrowsmith, Cheryl H.;Brown, Peter J.;Vedadi, Masoud;Jin, Jian [Journal of Medicinal Chemistry,2013,vol. 56,# 21,p. 8931 - 8942]