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1,3-부탄디올

1,3-부탄디올 구조식 이미지

카스 번호:: 107-88-0

한글명:: 1,3-부탄디올

동의어(한글):: 1,3-부탄디올;부탄디올(1,3);부틸렌글라이콜;1,3-부탄다이올

상품명:: 1,3-Butanediol

동의어(영문):: BD;Butane-1,3-diol;1,3-BUTYLENE GLYCOL;1,3-Butandiol;(3S)-butane-1,3-diol;3-Butanediol;BUTAN-1,3-DIOL;(±)-butane-1,3-diol;1-Methyl-1,3-propanediol;butane-1,

CBNumber:: CB7758265

분자식:: C4H10O2

포뮬러 무게:: 90.12

MOL 파일:: 107-88-0.mol

MSDS 파일:: SDS

속성

안전

MSDS

용도

공급 업체 601

1,3-부탄디올 속성

녹는점: -54 °C

끓는 점: 203-204 °C(lit.)

밀도: 1.005 g/mL at 25 °C(lit.)

증기 밀도: 3.1 (20 °C, vs air)

증기압: 0.06 mm Hg ( 20 °C)

굴절률: n20/D 1.44(lit.)

인화점: 250 °F

저장 조건: Store below +30°C.

용해도: >500g/l혼용 가능

물리적 상태: 액체

산도 계수 (pKa): 14.83±0.20(Predicted)

색상: 무색~황색 투명하며, 보관 시 갈색으로 변색될 수 있음

Specific Gravity: 1.004 – 1.007

냄새: 냄새 없는

pH 범위: 6 - 7 at 20 °C

수소이온지수(pH): 6.1 (500g/l, H2O, 20℃)

폭발한계: 1.9-12.6%(V)

수용성: 녹는

감도: Hygroscopic

Merck: 14,1567

BRN: 1731276

안정성: 안정적인. 가연성. 흡습성 - 공기와 습기로부터 보호합니다. 강한 산화제와 호환되지 않습니다.

LogP: -0.9 at 25℃

CAS 데이터베이스: 107-88-0(CAS DataBase Reference)

NIST: 1,3-Butanediol(107-88-0)

EPA: 1,3-Butylene glycol (107-88-0)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

안전지침서	24/25
WGK 독일	1
RTECS 번호	EK0440000
F 고인화성물질	3
자연 발화 온도	741 °F
TSCA	Yes
HS 번호	29053920
유해 물질 데이터	107-88-0(Hazardous Substances Data)
독성	LD50 orally in Rabbit: 18610 mg/kg LD50 dermal Rabbit > 20000 mg/kg
기존화학 물질	KE-03787

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고		P264, P280, P305+P351+P338,P337+P313P

예방조치문구:

P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P337+P313	눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.

NFPA 704

	1
1		0

1,3-부탄디올 MSDS

1,3-Butanediol

1,3-부탄디올 C화학적 특성, 용도, 생산

화학적 성질

colourless liquid

용도

1,3-Butanediol is used in the synthesis of colchicine derivatives as anticancer agents. Also used in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycem ic agents in the treatment of diabetes.

정의

ChEBI: A butanediol compound having two hydroxy groups in the 1- and 3-positions.

제조 방법

From formaldehyde and propylene via pressure and a catalyst.

생산 방법

Butylene glycol is prepared by catalytic hydrogenation of aldol using Raney nickel.

일반 설명

(±)-1,3-Butanediol (BD) is a 1,3-diol. Its vapor pressure upto 270kPa, liquid-phase densities over a temperature range, two-phase (liquid + vapor) heat capacities, critical temperature and critical density have been determined. The obtained data was employed to derive various thermophysical properties.

Pharmaceutical Applications

Butylene glycol is used as a solvent and cosolvent for injectables. It is used in topical ointments, creams, and lotions, and it is also used as a vehicle in transdermal patches. Butylene glycol is a good solvent for many pharmaceuticals, especially estrogenic substances.
In an oil-in-water emulsion, butylene glycol exerts its best antimicrobial effects at ～8% concentration. Higher concentrations above 16.7% are required to inhibit fungal growth.

색상 색인 번호

This dihydric alcohol is used for its humectant and preservative potentiator properties in cosmetics, topical medicaments and polyurethane, polyester, cellophane, and cigarettes. It has similar properties, but is less irritant than propylene glycol. Contact allergies seem to be rare.

Safety Profile

Mdly toxic by ingestion and subcutaneous routes. A skin and eye irritant. See also ETHYLENE GLYCOL. Experimental reproductive effects. Combustible when exposed to heat or flame. Incompatible with oxidizing materials. To fight fire, use foam, alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Butylene glycol is used in a wide variety of cosmetic formulations and is generally regarded as a relatively nontoxic material. It is mildly toxic by oral and subcutaneous routes.
In topical preparations, butylene glycol is regarded as minimally irritant. Butylene glycol can cause allergic contact dermatitis, with local sensitivity reported in patch tests. Some local irritation is produced on eye contact.
LD₅₀ (guinea pig, oral): 11.0 g/kg
LD₅₀ (mouse, oral): 12.98 g/kg
LD₅₀ (rat, oral): 18.61 g/kg
LD₅₀ (rat, SC): 20.0 g/kg

Carcinogenicity

There were no tumors found in the 2-year feeding studies on dogs and rats . Thus, it appears that 1,3-butanediol is not carcinogenic.

저장

Butylene glycol is hygroscopic and should be stored in a well-closed container in a cool, dry, well-ventilated place. When heated to decomposition, butylene glycol emits acrid smoke and irritating fumes.

비 호환성

Butylene glycol is incompatible with oxidizing reagents.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (transdermal patches). Included in licensed medicines in the UK (topical gel patches/medicated plasters).

1,3-부탄디올 준비 용품 및 원자재

원자재

프로필렌 n-뷰탈알데히드 알돌

준비 용품

1,3-Dimethoxybutane

1,3-부탄디올 공급 업체

글로벌( 601)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12470	58
Hebei Duling International Trade Co. LTD	+8618712993135	sales01@hbduling.cn	China	15734	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	18223	58
Hebei Saisier Technology Co., LTD	+86-18400010335 +86-18034520335	admin@hbsaisier.cn	China	938	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	2196	58
Hebei Longbang Technology Co., LTD	+86-18032476855 +86-18032476855	admin@hblongbang.com	China	735	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15956	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
Jiangsu Qingquan Chemical Co., Ltd.	+86-571-86589381,86589382,86589383	sales1@qqpharm.com	CHINA	154	55