Applications of 1-Fluoronaphthalene
Nov 1,2019
Fig 1. Chemical structure formula and three-dimensional structure of 1-Fluoronaphthalene
1-Fluonaphthalene (321-38-0) is a colorless to pale yellow transparent liquid. 1-Fluoronaphthalene is an organofluorine chemical compound from the group of naphthalene derivatives and fluoroaromatics. Its chemical formula is C10H7F. 1-Fluornaphthalene is an organofluorine chemical compound from the group of naphthalene derivatives and fluoroaromatics. It is a colorless, combustible liquid, which is insoluble in water. 1-Fluoronaphthalene can be obtained by reacting naphthalene with Selectfluor.
1-Fluoronaphthalene was used for the tert-butyllithium-mediated synthesis of 6-substituted phenanthridines. 1-Fluoronaphthalene has also been used in the synthesis of LY248686, a potent inhibitor of serotonin and norepinephrine uptake. 1-Fluoronaphthalene is also used as a component of the Organic Check Material mounted in canisters on Mars Science Laboratory Curiosity rover. 1-Fluoronaphthalene is used for calibrating the Sample Analysis at Mars (SAM) instrument suite, being a synthetic organic compound not found in nature on Earth and not expected on Mars.
The reactivity profile of 1-Fluoronaphthalene is that Simple aromatic halogenated organic compounds, such as Fluoronaphthalene, are very unreactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group may be incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.
1-Fluoronaphthalene is the key starting material in the synthetic route of duloxetine hydrochloride followed by Pharmathen. A reproducible stability-indicating RP-HPLC method was developed and validated as per ICH guidelines, for the quantitative determination of 1-fluoronaphthalene in the presence of its four process-related impurities: 1-aminonaphthalene, 1-nitronaphthalene, naphthalene and 2-fluoronaphthalene[1,2]. Based on the in process analysis performed in the laboratory in the final product of duloxetine HCl, only 1-fluoronaphthalene was found to be present in ,0.1%.
References
[1] International Conference on Harmonization Guideline on Stability Testing of New Drug Substances and Products, Q1A (R2);(2003).
[2] International Conference on Harmonization Guideline on Photo stability Testing of New Drug Substances and Products, Q1B (R2);(1996).
- Related articles
- Related Qustion
- 1-Fluoronaphthalene: detection method, applications and safety Oct 26, 2023
1-Fluoronaphthalene is a fluorinated aromatic compound used as a solvent additive in organic solar cell research, with safety precautions for handling.
- Applications of 1-Fluoronaphthalene Nov 1, 2019
1-Fluonaphthalene (321-38-0) is a colorless to pale yellow transparent liquid. 1-Fluoronaphthalene is an organofluorine chemical compound from the group of naphthalene derivatives and fluoroaromatics.
- The application of 1- flonaphthalene Aug 14, 2019
1-Fluornaphthalene is an organofluorine chemical compound from the group of naphthalene derivatives and fluoroaromatics. It is a colorless, combustible liquid, which is insoluble in water.
Capmatinib targets MET exon 14 skipping mutations, inhibiting proliferation and migration in non-small cell lung cancer. It has predictable pharmacokinetics and manageable adverse reactions.....
Mar 1,2024APILike many other supplements, melatonin supplements do expire. It have an expiration date because the active ingredients in melatonin pills can degrade over time, making them less effective.....
Mar 1,2024API1-Fluoronaphthalene
321-38-0You may like
- Tetraacetylethylenediamine and laundry detergents
Aug 19, 2024
- Triphosgene: History and Advantage
Aug 9, 2024
- The different types of Ethanol
Aug 9, 2024
1-Fluoronaphthalene manufacturers
- Fluoronaphthalene
-
- $10.50 / 1KG
- 2024-08-21
- CAS:321-38-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 ton
- 1-Fluoronaphthalene
-
- $0.00 / 25kg
- 2024-08-14
- CAS:321-38-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 50000KG/month
- 1-Fluoronaphthalene
-
- $80.00 / 1kg
- 2024-05-10
- CAS:321-38-0
- Min. Order: 10kg
- Purity: 0.99
- Supply Ability: 20tons