1184136-10-4
中文名称
UNC-926
CAS
1184136-10-4
分子式
C16H21BrN2O
分子量
337.25
MOL 文件
1184136-10-4.mol
更新日期
2024/11/20 16:00:09
1184136-10-4 结构式
基本信息
中文别名
化合物UNC 926 HYDROCHLORIDE 英文别名
UNC-926UNC-926 Hydochloride
UNC-926 Hydrochloride
UNC926
UNC-926
UNC 926
(3-bromophenyl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone
(3-Bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]-methanone
Methanone, (3-bromophenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]-
(3-Bromophenyl)[4-(1-prrolidinyl)-1-piperidinyl]methanone hydrochloride
应用领域
用途1
UNC-926 is a methyl-lysine reader antagonist; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 渭M). UNC-926 selectively inhibits the interaction between L3MBTL13XMBT-H4K20me1 in a peptide pull
down assay.常见问题列表
生物活性
UNC926 是一种 methyl-lysine (Kme) reader domain 抑制剂，可特异性抑制 L3MBTL1，其 IC50 为 3.9 μM。靶点
| Target | Value |
|
L3MBTL1
() | 3.9 μM(Kd) |
体外研究
UNC926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3 ( IC
50
of 3.2 μM), with a decrease in affinity for the other MBT domains and no binding to CBX7.
UNC926 (1-25 μM) inhibits binding of the 3xMBT domain to H4K20me1.UNC926 inhibits the association of L3MBTL13xMBT with the appropriate histonepeptides in a dose-dependent manner. UNC926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC926 for L3MBTL1 over 53BP1.