1320288-17-2
中文名称
N-(1-环己基-4-哌啶基)-2-[六氢-4-异丙基-1H-1,4-二氮杂卓-1-基]-6-甲氧基-7-[3-(1-哌啶基)丙氧基]-4-喹唑啉胺
英文名称
UNC0646
CAS
1320288-17-2
分子式
C36H59N7O2
分子量
621.9
MOL 文件
1320288-17-2.mol
更新日期
2024/06/27 11:27:24
1320288-17-2 结构式
基本信息
中文别名
G9A抑制剂(UNC0646)N-(1-环己基-4-哌啶基)-2-[六氢-4-异丙基-1H-1,4-二氮杂卓-1-基]-6-甲氧基-7-[3-(1-哌啶基)丙氧基]-4-喹唑啉胺
英文别名
CS-792UNC0646
UNC0646/UNC-0646
UNC 0646
UNC0646
UNC-0646
N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-Methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-aMine
N-(1-Cyclohexyl-4-piperidinyl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
(1-CYCLOHEXYL-PIPERIDIN-4-YL)-[2-(4-ISOPROPYL-[1,4]DIAZEPAN-1-YL)-6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)-QUINAZOLIN-4-YL]-AMINE
N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
4-Quinazolinamine, N-(1-cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点754.6±70.0 °C(Predicted)
密度1.128±0.06 g/cm3(Predicted)
储存条件Keep in dark place,Sealed in dry,2-8°C
溶解度DMSO：可溶，2mg/mL，澄清（加热）
酸度系数(pKa)9.34±0.70(Predicted)
形态粉末
颜色白色至米色
常见问题列表
生物活性
UNC0646是一种选择性的组蛋白赖氨酸甲基转移酶(HMTase)抑制剂，作用于G9a和GLP，IC50分别为6 nM和15 nM 。在多种细胞系中活性较强，也能有效的将功能性活性于细胞毒性区分。靶点
| Target | Value |
|
G9a
(Cell-free assay) | 6 nM |
|
GLP
(Cell-free assay) | 15 nM |
体外研究
UNC0646 (Compound 6) has high cellular potency and excellent separation of functional potency versus cell toxicity in a variety of cell lines. UNC0646 is highly potent in reducing H3K9me2 levels and has low cell toxicity. UNC0646 reduces H3K9me2 levels with ICW IC 50 values of 26 nM, 10 nM, 12 nM, 14 nM, 68 nM, 86 nM and 10 nM in MDA-MB-231, MCF7, PC3, 22RV1, HCT116 wt, HCT 116 p53 -/- and IMR90 cell lines, respectively.