1320288-19-4
1320288-19-4 结构式
基本信息
中文别名
G9A抑制剂(UNC 0631)N-[1-(环己基甲基)-4-哌啶基]-2-[六氢-4-异丙基-1H-1,4-二氮杂卓-1-基]-6-甲氧基-7-[3-(1-哌啶基)丙氧基]-4-喹唑啉胺
英文别名
CS-793UNC 0631
UNC 0631, >=98%
UNC0631/UNC-0631
UNC 0631 USP/EP/BP
UNC0631
UNC 0631
UNC-0631
N-[1-(Cyclohexylmethyl)-4-piperidinyl]-2-(4-isopropyl-1,4-diazepa n-1-yl)-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
N-(1-(cyclohexylmethyl)piperidin-4- yl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-(3-(piperidin-1- yl)propoxy)quinazolin-4-amine
N-[1-(CyclohexylMethyl)-4-piperidinyl]-2-[hexahydro-4-(1-Methylethyl)-1H-1,4-diazepin-1-yl]-6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinaMine
4-Quinazolinamine, N-[1-(cyclohexylmethyl)-4-piperidinyl]-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-
所属类别
生物化工：Histone Methyltransferase 抑制剂物理化学性质
沸点763.4±70.0 °C(Predicted)
密度1.114±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度insoluble in H2O; ≥12.66 mg/mL in EtOH with ultrasonic; ≥18.35 mg/mL in DMSO with gentle warming
酸度系数(pKa)9.34±0.70(Predicted)
形态固体
颜色Light yellow to yellow
常见问题列表
生物活性
UNC 0631 是一种有效的组蛋白甲基转移酶 G9a 抑制剂，IC50 值为 4 nM。UNC 0631 有效降低 MDA-MB-231 细胞中 H3K9me2 的水平，IC50 为 25 nM。靶点
|
G9a 4 nM (IC 50 ) |
体外研究
UNC 0631 (Compound 7) has high cellular potency and excellent separation of functional potency versus cell toxicity in a variety of cell lines. UNC 0631 is highly potent in reducing H3K9me2 levels and has low cell toxicity. UNC 0631 reduces H3K9me2 levels with ICW IC 50 values of 25 nM, 18 nM, 26 nM, 24 nM, 51 nM, 72 nM and 46 nM in MDA-MB-231, MCF7, PC3, 22RV1, HCT116 wt, HCT 116 p53 -/- and IMR90 cell lines, respectively.