1395084-25-9
1395084-25-9 结构式
基本信息
4-[(1E)-2-(2-氨基-4-羟基-5-甲基苯基)偶氮]-N-2-吡啶基苯磺酰胺
CS-1882
MS436(95%)
MS 436, >=98%
MS-436
MS 436
MS436 USP/EP/BP
(E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide
(E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE
4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide
Benzenesulfonamide, 4-[(1E)-2-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinyl-
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-13959 | (E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE MS436 | 1395084-25-9 | 5mg | 750元 |
| 2024/08/19 | HY-13959 | (E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE MS436 | 1395084-25-9 | 10mM * 1mLin DMSO | 825元 |
| 2024/08/19 | HY-13959 | (E)-4-((2-AMINO-4-HYDROXY-5-METHYLPHENYL)DIAZENYL)-N-(PYRIDIN-2-YL)BENZENESULFONAMIDE MS436 | 1395084-25-9 | 10mg | 1300元 |
常见问题列表
Ki: 30-50 nM (BRD4 bromodomain)
MS436, through a set of water-mediated interactions, exhibits low nanomolar affinity (estimated K i of 30-50 nM) with preference for the first bromodomain over the second. MS436 effectively inhibits BRD4 activity in NF-κB-directed production of NO and pro-inflammatory cytokine interleukin-6 in murine macrophages. MS436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression. MS436 exhibits potent affinity of an estimated K i =30-50 nM for the BRD4 BrD1 and a 10-fold selectivity over the BrD2, which is achieved through a unique set of water-mediated intermolecular interactions.