151096-09-2
151096-09-2 结构式
基本信息
莫西沙星
(4ΑS-CIS)-1-环丙基-6-氟-1,4-二氢-8-甲氧基-7-(六氢-6H-吡咯[3,4-B] 吡啶-6-基)-4-氧-3-喹啉羧酸
(1'S,6'S)-1-Cyclopropyl-7-(2,8-diazabicyclo[4.3.0]non-8-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
MAXIOFFOXACIN
(4αS-cis)-1-Cydopropyl-6-fluoro-1，4-dihydro-8-methoxy-7-(octahydro-6H-pyrrolo[3，4-b]pyridin-6-y1)-4-oxo-3-quinolinecarboxylic acid
Avdox
物理化学性质
制备方法
常见问题列表
莫西沙星最常见的不良反应包括：恶心、腹泻、头痛和头晕以及心脏Q-T间期延长。
较少见的不良反应，包括全身反应（如过敏反应等）、心血管系统反应（如高血压、心悸）、消化系统反应（如腹痛、厌食、便秘、消化不良等）、骨骼肌肉系统反应（如关节痛、肌肉痛）、神经系统反应（如激动、焦虑、失眠、紧张、感觉异常等）、呼吸系统反应（如呼吸困难）、皮肤软组织系统反应（如瘙痒、皮疹、多汗等）。
此外，莫西沙星还可能导致部分实验室检验异常，如中性粒细胞减少，碱性磷酸酶、血清尿素氮、血清肌酐升高等。
1）如果口服莫西沙星，请固定在每天同一时间服药，餐前餐后均可；如果静脉滴注莫西沙星，请至少滴注90分钟；
2）用药后接触阳光或紫外线，可能引起严重的光过敏，出现过度晒伤的症状，所以用药期间请采取防晒措施；
3）莫西沙星可能引起头晕等情况，用药期间尽量避免驾驶等危险行为；
4）用药后可能会干扰血糖，如果糖尿病患者使用，请注意监测血糖；
用药后可能引发严重副作用，如肌腱炎、肌腱断裂、周围神经病变及中枢神经系统副作用，或加重重症肌无力，如果出现以上副作用，请停药并联系医师，避免再次用药。
Bacterial
The in vitro activities of Moxifloxacin and Amoxicillin are compared by time-kill curve and inhibition of intracellular growth experiments by using a model of bone marrow-derived mouse macrophages infected by L. monocytogenes EGDe. Moxifloxacin acts much more rapidly, beginning to exert its effects in the first 3 h and achieving complete broth sterilization within 24 h of incubation. Moxifloxacin appears to have a protective effect against macrophage lysis, as many cells are still viable after 24 h of incubation.
Moxifloxacin (12 mg/kg; intravenous injection; once-three times per day; for 7 days; white male Wistar rats) treatment every 8 hours is accompanied by longer survival. Tissue cultures 30 hours after bacterial challenge shows considerably less bacterial overgrowth in the spleens and lungs of moxifloxacin-treated than in salinetreated animals and without being toxic.
| Animal Model: | 144 white male Wistar rats (18-22 weeks; 300-400 g) infected Stenotrophomonas maltophilia |
| Dosage: | 12 mg/kg |
| Administration: | Intravenous injection; once per day, twice per day, three times per day; for 7 days |
| Result: | Showed considerably less bacterial overgrowth in the spleens and lungs and without being toxic. |