906-33-2
906-33-2 结构式
基本信息
新綠原酸
5-咖啡奎宁酸
5-咖啡酰奎宁酸
5-咖啡酰奎尼酸
5-二咖啡酰奎宁酸
新绿原酸 10MG
新绿原酸(标准品)
新绿原酸(5-咖啡酰奎宁酸)
5-二咖啡酰奎宁酸,新绿原酸
Einecs 212-997-1
Neochlorogenic aci
Nochlorogenic acid
Neochlorogenic acid
5-Caffeoylquinic acid
5-O-CAFFEOYLQUINICACID
Neochlorogenic acid(3')
5-Dicaffeoylquinic Acid
(E)-Neochlorogenic Acid
物理化学性质
常见问题列表
绿原酸亦称“绿吉酸”、“咖啡单宁酸”。分子式C16H18O9。分子量354.32。由水中得针状结晶，为半水合物，110℃变为无水合物。熔点208℃，[α]D25-33.5°(水，C=1)，K=2.2×10-3(27℃)。有弱酸味并具收敛性。25℃时在水中溶解度为4%，较易溶于热水，溶于乙醇、丙酮，微溶于乙酸乙酯，不溶于氯仿、乙醚和二硫化碳。与浓盐酸共沸得蓝色染料。能使溴水褪色，与浓碘化氢共沸得苯甲酸，与水在230℃共热分解为苯酚，与稀盐酸共热分解为咖啡酸和金鸡纳酸等，室温与稀碱作用只得咖啡酸和金鸡纳酸。
绿原酸为植物代谢的重要因素，绿原酸及其异构体异绿原酸和新绿原酸也存在于双子叶植物的果实、叶及其他组织中。绿原酸为3-咖啡酸喹宁酸。新绿原酸为5-咖啡酸喹宁酸。异绿原酸含三种咖啡酰喹宁酸类物质，分别为4，5-二咖啡酰喹宁酸，3，4-二咖啡酰喹宁酸，3，5-二咖啡酰喹宁酸。
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p65
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IL-1β
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TNF-α
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COX-2
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Neochlorogenic acid (NCA) shows a reduction of lipopolysaccharide (LPS)-induced NO production by suppressing iNOS and COX-2 protein expression and production of pro-inflammatory cytokines, such as TNF-α and IL-1β, in BV2 microglia cells. In addition, phosphorylated p38 MAPK and NF-κB p65 are also inhibited by Neochlorogenic acid in activated microglia. iNOS and COX-2 levels are increased in LPS-induced BV2 cells, but this increase is significantly inhibited after treatment with 50 and 100 μM Neochlorogenic acid.