Astragaloside IV

Astragaloside IV Struktur
83207-58-3
CAS-Nr.
83207-58-3
Englisch Name:
Astragaloside IV
Synonyma:
Astragaloside IV;Astramembrannin i;Astragalin A;astragaloside A;Astragaloside IV;Astragaloside A 5%;ASTRAGALOSIDE IV(P);Astragaloside IV(A);Astragaloside IV CRS;Astragaloside IV ,98%
CBNumber:
CB0500944
Summenformel:
C41H68O14
Molgewicht:
784.97
MOL-Datei:
83207-58-3.mol

Astragaloside IV Eigenschaften

Siedepunkt:
895.7±65.0 °C(Predicted)
Dichte
1.39±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
Löslichkeit
DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
Aggregatzustand
A crystalline solid
pka
12.91±0.70(Predicted)
InChIKey
QMNWISYXSJWHRY-APZLXCBQNA-N
LogP
0.628 (est)
CAS Datenbank
83207-58-3

Sicherheit

HS Code  29389090

Astragaloside IV Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Astragalosides are bioactive saponins isolated from dried roots of plants of the genus Astragalus, which is used in traditional Chinese medicine. Astragaloside A, also known as astragaloside IV, is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. More specifically, it protects cardiomyocytes from apoptosis resulting from ischemia/reperfusion and inhibits inflammation signaled through TNF-α. Furthermore, astragaloside A stimulates angiogenesis, promotes the differentiation of neural stem cells, and increases neuroregeneration.

Definition

ChEBI: A pentacyclic triterpenoid that is cycloastragenol having beta-D-xylopyranosyl and beta-D-glucopyranosyl residues attached at positions O-3 and O-6 respectively. It is isolated from <ital Astragalus membranaceus var mongholicus.

benefits

Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. It is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. Astragaloside IV improves post-ischemic heart function and ameliorated reperfusion arrhythmias accompanied by a significant increase in myocardial antioxidative enzyme superoxide dismutase activity in rat hearts in vitro. While, Astragaloside IV's protective effect on heart function can be partially abrogated by the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine methyl ester.

Pharmazeutische Anwendungen

Astrageloside A has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, Astragaloside A possesses potential for broad application in many diseases.

Mode of action

Astragaloside IV is a well-known AM compound known for its neuroprotective effects. It acts as an antioxidant and reduces cell inflammation and oxidative stress. Astragaloside IV helps protect dopaminergic neurons and promotes neural process outgrowth, potentially therapeutic in PD. All the benefits of this compound for neurodegenerative diseases such as AD, PD, cerebral ischemia, and autoimmune encephalomyelitis. AS-IV maintains dopamine synthesis by increasing enzymes tyrosine hydroxylase (TH) and nitric oxide synthase (NOS), which are involved in neuron production pathways, neural signalling, and cell immune responses. The other mechanism of AS-IV in PD disease is the prevention of neuron pathology by a neurotoxicant called 1-methyl-4-phenylpyridium ion (MPP+) throughout the increasing cell survival, inhibiting pro-apoptosis Bax-mediated pathway and caspase protein (Caspase-3) activity which can destroy cellular structures while increasing anti-apoptosis B-cell lymphoma 2 (Bcl-2). It also protects neuron mitochondria from apoptosis and DNA damage by inducing Akt to promote binding of hexokinase-II (HK-II) and mitochondria for the protection of neural mitochondria[1].

Astragaloside IV Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Astragaloside IV Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 182)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd.
+86-0086-025-69916489 +86-18852044786
tongyuansales@vip.sina.com China 323 58
Changsha Staherb Natural Ingredients Co., Ltd.
+86-0731-84213302 +8618374838656
sales@staherb.cn China 1025 58
Chengdu King-tiger Pharm-chem. Tech. Co., Ltd.
028-85317716 18202897410
sales@king-tiger.com China 7 58
Hebei Duling International Trade Co. LTD
+8617333973358
sales01@hbduling.cn China 15438 58
Hebei Kingfiner Technology Development Co.Ltd
+86-15532196582 +86-15373005021
lisa@kingfinertech.com China 2989 58
Shaanxi Haibo Biotechnology Co., Ltd
+undefined18602966907
qinhe02@xaltbio.com China 1000 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20361 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618740459177
sarah@tnjone.com China 1142 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21676 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714
fandachem@gmail.com China 9338 55

83207-58-3()Verwandte Suche:


  • ASTRAGALOSIDE IV(P)
  • astragaloside A
  • Astragaloside IV ,98%
  • Astragaloside IV(A)
  • Astragaloside A(Astragaloside IV)
  • beta-D-Glucopyranoside, (3beta,6alpha,16beta,24R)-20,24-epoxy-16,25-dihydroxy-3-(beta-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl
  • β-D-Glucopyranoside, (3β,6α,16β,24R)-20,24-epoxy-16,25-dihydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl
  • Astragalus Extract Astragaloside IV
  • Astragaloside IV-Astragaloside A
  • Astragaloside IV CRS
  • Astragalin A
  • Astragaloside A USP/EP/BP
  • Astragaloside A 5%
  • b-D-Glucopyranoside, (3b,6a,16b,24R)-20,24-epoxy-16,25-dihydroxy-3-(b-D-xylopyranosyloxy)-9,19-cyclolanostan-6-yl
  • Astragaloside A (Astramembrannin I
  • Astragaloside IV
  • Astramembrannin i
  • astragalus polysaccharide concentrated extract
  • Astragalus methylside
  • (2R,3R,4S,5S,6R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4-Hydroxy-3-((2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyl-9-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)hexadecahydrocyclopenta[a]cyclopropa[e]phenanthren-7-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
  • Astragaloside IV
  • 83207-58-3
  • Inhibitors
  • API
  • Plant extracts
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