Astragaloside IV
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Astragaloside IV 속성
- 끓는 점
- 895.7±65.0 °C(Predicted)
- 밀도
- 1.39±0.1 g/cm3(Predicted)
- 저장 조건
- under inert gas (nitrogen or Argon) at 2-8°C
- 용해도
- DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
- 물리적 상태
- 결정성 고체
- 산도 계수 (pKa)
- 12.91±0.70(Predicted)
- InChIKey
- QMNWISYXSJWHRY-APZLXCBQNA-N
- LogP
- 0.628 (est)
- CAS 데이터베이스
- 83207-58-3
안전
HS 번호 | 29389090 |
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Astragaloside IV C화학적 특성, 용도, 생산
용도
Astragalosides are bioactive saponins isolated from dried roots of plants of the genus Astragalus, which is used in traditional Chinese medicine. Astragaloside A, also known as astragaloside IV, is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. More specifically, it protects cardiomyocytes from apoptosis resulting from ischemia/reperfusion and inhibits inflammation signaled through TNF-α. Furthermore, astragaloside A stimulates angiogenesis, promotes the differentiation of neural stem cells, and increases neuroregeneration.정의
ChEBI: A pentacyclic triterpenoid that is cycloastragenol having beta-D-xylopyranosyl and beta-D-glucopyranosyl residues attached at positions O-3 and O-6 respectively. It is isolated from <ital Astragalus membranaceus var mongholicus.benefits
Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. It is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. Astragaloside IV improves post-ischemic heart function and ameliorated reperfusion arrhythmias accompanied by a significant increase in myocardial antioxidative enzyme superoxide dismutase activity in rat hearts in vitro. While, Astragaloside IV's protective effect on heart function can be partially abrogated by the nitric oxide synthase inhibitor, Nomega-nitro-L-arginine methyl ester.Pharmaceutical Applications
Astrageloside A has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, Astragaloside A possesses potential for broad application in many diseases.Mode of action
Astragaloside IV is a well-known AM compound known for its neuroprotective effects. It acts as an antioxidant and reduces cell inflammation and oxidative stress. Astragaloside IV helps protect dopaminergic neurons and promotes neural process outgrowth, potentially therapeutic in PD. All the benefits of this compound for neurodegenerative diseases such as AD, PD, cerebral ischemia, and autoimmune encephalomyelitis. AS-IV maintains dopamine synthesis by increasing enzymes tyrosine hydroxylase (TH) and nitric oxide synthase (NOS), which are involved in neuron production pathways, neural signalling, and cell immune responses. The other mechanism of AS-IV in PD disease is the prevention of neuron pathology by a neurotoxicant called 1-methyl-4-phenylpyridium ion (MPP+) throughout the increasing cell survival, inhibiting pro-apoptosis Bax-mediated pathway and caspase protein (Caspase-3) activity which can destroy cellular structures while increasing anti-apoptosis B-cell lymphoma 2 (Bcl-2). It also protects neuron mitochondria from apoptosis and DNA damage by inducing Akt to promote binding of hexokinase-II (HK-II) and mitochondria for the protection of neural mitochondria[1].Astragaloside IV 준비 용품 및 원자재
원자재
준비 용품
Astragaloside IV 공급 업체
글로벌( 186)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd. | +86-0086-025-69916489 +86-18852044786 |
tongyuansales@vip.sina.com | China | 323 | 58 |
Changsha Staherb Natural Ingredients Co., Ltd. | +86-0731-84213302 +86-18374838656 |
info@staherb.cn | China | 1025 | 58 |
Chengdu King-tiger Pharm-chem. Tech. Co., Ltd. | 028-85317716 18202897410 |
sales@king-tiger.com | China | 6 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 |
lisa@kingfinertech.com | China | 2989 | 58 |
Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 |
qinhe02@xaltbio.com | China | 1000 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20294 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9332 | 55 |
NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 |
sale02@cqherb.com | CHINA | 376 | 58 |
Astragaloside IV 관련 검색:
4-터트-뷰틸사이클로헥사놀 황기
1,1,2,2-TETRAMETHYLCYCLOPROPANE
Astragaloside VI
AstragalosideⅠ
CYCLOPENTADECANE
Menthoxypropanediol
CYCLOPENTADECANOL
Astragalin Astragaloside II,Astragaloside B,Astragaloside-Ⅱ,ASTRAGALOSIDE II
Astragaloside III,Astragaloside-Ⅲ
ASTRAGALOSIDE I
2-METHYLPENTACOSANE
1,1-DIETHYLCYCLOPROPANE
2-(TRANS-4'-N-BUTYL-CYCLOHEXYL)PROPANE-1,3-DIOL
2-(TRANS-4-PENTYLCYCLOHEXYL)PROPANE-1,3-DIOL
ASTRAGALOSIDE
Astragaloside VII
Astragalus P.E Astragaloside 0.3%,10% HPLC