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Glichidon

Gliquidone Struktur
33342-05-1
CAS-Nr.
33342-05-1
Bezeichnung:
Glichidon
Englisch Name:
Gliquidone
Synonyma:
ardf26;ardf26se;Glurenorm;GLIQUIDONE;Gliquidone>Gliquidone D6;D6-Gliquidone;GLIQUIDONE 99%;Gliquidone powder;Gliquidone Tablets
CBNumber:
CB1183076
Summenformel:
C27H33N3O6S
Molgewicht:
527.63
MOL-Datei:
33342-05-1.mol
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Glichidon Eigenschaften

Schmelzpunkt:
179 °C
Dichte
1.34±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
Löslichkeit
≥22.4 mg/mL in DMSO; insoluble in H2O; ≥2.455 mg/mL in EtOH with gentle warming and ultrasonic
Aggregatzustand
powder to crystal
pka
5.12±0.10(Predicted)
Farbe
White to Almost white
Merck 
14,4443
InChIKey
LLJFMFZYVVLQKT-UHFFFAOYSA-N
SMILES
C1(S(NC(NC2CCCCC2)=O)(=O)=O)=CC=C(CCN2C(=O)C(C)(C)C3=C(C2=O)C=C(OC)C=C3)C=C1
CAS Datenbank
33342-05-1(CAS DataBase Reference)

Sicherheit

S-Sätze: 24/25
WGK Germany  WGK 3
RTECS-Nr. DB1584250
HS Code  29147000
Speicherklasse 11 - Combustible Solids

Glichidon Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Gliquidone is a second generation sulfonylurea that selectively inhibits ATP-sensitive potassium channel currents (IKATP) in pancreatic β-cells (IC50s = 0.45, 119.1, and 149.7 μM for HIT-T15 cells, cardiomyocytes, and vascular smooth muscle cells, respectively). It is also a peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 10 μM in a transactivation assay). Gliquidone (0.2 nmol/g) decreases plasma levels of D-glucose and stimulates insulin release in anesthetized rats. It decreases blood glucose levels, serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activities, and hepatic lipid peroxidation and increases hepatic glutathione (GSH) levels in a rat model of diabetes induced by streptozotocin (STZ; ) when administered at a dose of 10 mg/kg.

Verwenden

Gliquidone is an anti diabetic agent used in the treatment of hypoglycemia which leads to an increased risk in diabetic cardiovascular disease. Also used in the treatment diabetic nephropathy.

Hazard

Low toxicity by ingestion. A reproductive hazard.

Glichidon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Cyclohexylisocyanat 6-bromo-1,2,3,4-tetrahydro-4,4-dimethylquinoline hydrochloride 4,4'-Sulfonyldiphenol Potassium T-Butylate p-[2-(3,4-Dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isochinolyl)ethyl]benzolsulfonamid

Downstream Produkte

Glichidon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 312)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Weideli Chemical Reagent Co., Ltd. 13429867250 13429867250
 w13429867250@163.com China 1926 58
J & K SCIENTIFIC LTD. 18210857532 18210857532
 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109
 market03@meryer.com China 40202 62
Chembest Research Laboratories Limited 021-20908456
sales@BioChemBest.com China 5996 61
TCI (Shanghai) Development Co., Ltd. 021-67121386
Sales-CN@TCIchemicals.com China 24512 81
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418
sales@chemreagents.com United States 10174 62
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2110 70
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065
 sales@shlschem.com China 9880 59
Beijing Lunarsun Pharmaceutical Co.,LTD. 86-10-64911848-8020.8010
sales@lunarsun.com.cn China 95 60
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960
 info@chemlin.com.cn China 15342 64

33342-05-1(Glichidon)Verwandte Suche:

4-Methoxy-anilin Methoxyessigsäure 2-Methoxyphenol Anisol Anisaldehyd Chlorthal-dimethyl Dimethylcarbonat Methoxydiethylborane Dimethylsulfat (Trifluormethoxy)benzol Dimethylfumarat 3-Methoxybenzylalkohol Dimethylphthalat Dimethylsulfoxid N,N-Dimethylformamid Ethan POLY(ETHYLENE GLYCOL) METHYL ETHER ACRYLATE Dimethyl ether
  • ,4-dimethyl-1,3-dioxo-2(1h)-isoquinolinyl)ethyl)-
  • ardf26
  • ardf26se
  • benzenesulfonamide,n-((cyclohexylamino)carbonyl)-4-(2-(3,4-dihydro-7-methoxy-4
  • GLIQUIDONE 99%
  • GLIQUIDONE
  • Gliquidone Tablets
  • Glurenorm
  • N-[(Cyclohexylamino)carbonyl]-4-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2(1H)-yl)ethyl]benzenesulfonamide
  • 3-Cyclohexyl-1-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-isoquinolin-2-yl)ethyl]phenyl]sulfonyl-urea
  • Benzenesulfonamide, N-[(cyclohexylamino)carbonyl]-4-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolinyl)ethyl]-
  • Gliquidone, 98%, an anti-diabetic compound
  • Gliquidone 33342-05-1
  • 1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea
  • Gliquidone, 98%, anti-diabetic compound
  • 1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-2-isoquinolinyl)ethyl]phenyl]sulfonylurea
  • Gliquidone>
  • Gliquidone Gliquidone
  • Gliquidone Suphonamide
  • Gliquidone USP/EP/BP
  • Gliquidone powder
  • Gliquidone (AR-DF26)
  • Gliquidone D6
  • GliquidoneQ: What is Gliquidone Q: What is the CAS Number of Gliquidone Q: What is the storage condition of Gliquidone
  • Gliquidone reference
  • 3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea
  • N-[(cyclohexylamino)carbonyl]-4-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolinyl)ethyl]-benzenesulfonamide
  • N-(Cyclohexylcarbamoyl)-4-(2-(7-methoxy-4,4-dimethyl-1,3-dioxo-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)benzenesulfonamide
  • C14026000 Gliquidone
  • Gliquidone, 10 mM in DMSO
  • D6-Gliquidone
  • 1-cyclohexyl-3-({4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]benzene}sulfonyl)urea
  • Gliquidone (Standard)
  • 33342-05-1
  • 3342-05-1
  • C27H33N3O6S
  • Glurenorm
  • API
  • Active Pharmaceutical Ingredients
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