Kinsenoside

Kinsenoside Struktur
151870-74-5
CAS-Nr.
151870-74-5
Englisch Name:
Kinsenoside
Synonyma:
Kinsenoside;(+)-Kinsenoside;(4R)-4-(beta-D-Glucopyranosyloxy)dihydro-2(3H)-furanone;2(3H)-Furanone, 4-(β-D-glucopyranosyloxy)dihydro-, (4R)-;(4R)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-one;(R)-4-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)dihydrofuran-2(3H)-one;Keap1-Nrf2,Inhibitor,pulposus,disc,degeneration,Kinsenoside,inhibit,cells,nucleus,Nrf2,Apoptosis,intervertebral
CBNumber:
CB22645474
Summenformel:
C10H16O8
Molgewicht:
264.23
MOL-Datei:
151870-74-5.mol

Kinsenoside Eigenschaften

Siedepunkt:
570.2±50.0 °C(Predicted)
Dichte
1.59±0.1 g/cm3(Predicted)
storage temp. 
4°C, protect from light
Löslichkeit
DMF:14.0(Max Conc. mg/mL);52.98(Max Conc. mM)
DMSO:33.0(Max Conc. mg/mL);124.89(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);37.85(Max Conc. mM)
Aggregatzustand
A crystalline solid
pka
12.81±0.70(Predicted)
Farbe
White to light yellow

Sicherheit

Kinsenoside Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Kinsenoside is a glycoside originally isolated from A. formosanus that has diverse biological activities, including antihyperlipidemic, immunosuppressive, and anti-inflammatory properties. It increases lipolysis mediated by adipose triglyceride lipase and increases hydrolysis of triglycerides in C3H10T1/2 adipocytes. It also increases phosphorylation of peroxisome proliferator-activated receptor α (PPARα) and CREB as well as protein levels of SIRT1, PGC-1α, and carnitine palmitoyltransferase I. Kinsenoside downregulates the expression and phosphorylation of VEGF receptor 2 (VEGFR2) and inhibits crosstalk between the JAK2/STAT3 and PI3K/AKT signaling pathways in dendritic cells in vitro. It decreases the production of IFN-γ, IL-17, and TNF-α and increases the production of IL-10 in splenocytes isolated from mice with collagen-induced arthritis (CIA). Kinsenoside (300 mg/kg per day) decreases the expression of IL-1β, TNF-α, and matrix metalloproteinase-9 (MMP-9) and increases the expression of IL-10 in inflamed joints in a mouse model of collagen-induced arthritis and prevents paw edema and reduces the severity of arthritis.

Verwenden

Kinsenoside is an anti-hyperlipidemic agent isolated from the plant Anoect chilus.

Kinsenoside Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Kinsenoside Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 107)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3620 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897
sales@biopurify.com China 3424 58
Shanghai Standard Technology Co., Ltd.
18502101150
ft-sales@nature-standard.com CHINA 1923 58
Neostar United (Changzhou) Industrial Co., Ltd.
+86-519-519-85557386
marketing1@neostarunited.com China 12363 58
Wuhan ChemNorm Biotech Co.,Ltd.
+86-27-8439 4403 18971486879
sales@chemnorm.com CHINA 2935 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10326 58
Career Henan Chemica Co
+86-0371-86658258 15093356674;
laboratory@coreychem.com China 30254 58
Aktin Chemicals, Inc.
028-85159085
info@aktinchem.com CHINA 1025 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6313 58

151870-74-5()Verwandte Suche:


  • Kinsenoside
  • (4R)-4-(beta-D-Glucopyranosyloxy)dihydro-2(3H)-furanone
  • 2(3H)-Furanone, 4-(β-D-glucopyranosyloxy)dihydro-, (4R)-
  • (4R)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-one
  • (+)-Kinsenoside
  • Keap1-Nrf2,Inhibitor,pulposus,disc,degeneration,Kinsenoside,inhibit,cells,nucleus,Nrf2,Apoptosis,intervertebral
  • (R)-4-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)dihydrofuran-2(3H)-one
  • 151870-74-5
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