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(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline

(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline Struktur
1161002-05-6
CAS-Nr.
1161002-05-6
Englisch Name:
(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline
Synonyma:
H37;G-15;RMB5;LUCA15;AGPAT1;1-AGPAT1;LPAAT-alpha;G15;G-15;G 15;1161002-05-6;RNA binding motif protein 5;Compound G15 - GPR30 antagonist
CBNumber:
CB32518797
Summenformel:
C19H16BrNO2
Molgewicht:
370.24
MOL-Datei:
1161002-05-6.mol
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(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline Eigenschaften

Schmelzpunkt:
178-180 °C
Siedepunkt:
462.7±45.0 °C(Predicted)
Dichte
1.472±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
insoluble in H2O; insoluble in EtOH; ≥37 mg/mL in DMSO
Aggregatzustand
solid
pka
3.98±0.40(Predicted)
Farbe
White to off-white

Sicherheit

(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

G protein-coupled estrogen receptor (GPER), or GPR30, specifically binds natural and man-made estrogens. It is thought to be involved in estrogen-sensitive cancers. GPER knockout mice are fertile, although they exhibit thymic atrophy, impaired glucose tolerance, and altered bone growth. G-15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM). It displays low affinity cross-reactivity with the classical estrogen receptor (ER), ERα, so that at doses greater than 1 μM it is capable of mediating limited ER-dependent transcriptional activity. G-15 antagonizes the anti-depressive effects of estrogen in vivo.

Verwenden

(3aS,4R,9bR)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline is also known as “G-15”, a G-protein-coupled estrogen receptor antagonist designed for the treatment of estrogen-sensitive cancers.

(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 64)Lieferanten
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Hubei Jusheng Technology Co.,Ltd. 		18871490254
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3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
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Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979
info@tsbiochem.com China 8073 58
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396
 sales@chem-strong.com China 18018 56
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772
 huahero21@sina.com China 374 55

1161002-05-6()Verwandte Suche:

Deferoxaminmesilat 2-Brom-12'-hydroxy-5'α-isobutyl-2'-isopropylergotaman-3',6',18-trionmonomethansulfonat Phorbol-(12-myristol-13-acetyl) Oxytocin Silber
  • G-15
  • (3aS,4R,9bR)-4-(6-BroMo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
  • H37
  • LUCA15
  • RMB5
  • RNA binding motif protein 5
  • 1-AGPAT1
  • AGPAT1
  • Anti-AGPAT1 antibody produced in rabbit
  • LPAAT-alpha
  • (3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline
  • G15;G-15;G 15;1161002-05-6
  • (3aR,4R,9bS)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
  • (3aS,4R,9bR)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline (G-15)
  • 3H-Cyclopenta[c]quinoline, 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-, (3aS,4R,9bR)-
  • Compound G15 - GPR30 antagonist
  • (3aS,4R,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
  • Inhibitor,inhibit,G-15,G15,Estrogen Receptor/ERR,G 15
  • 1161002-05-6
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