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ChemicalBook >제품 카탈로그 >(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline

(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline

(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline 구조식 이미지
카스 번호:
1161002-05-6
상품명:
(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline
동의어(영문):
H37;G-15;RMB5;LUCA15;AGPAT1;1-AGPAT1;LPAAT-alpha;G15;G-15;G 15;1161002-05-6;RNA binding motif protein 5;Compound G15 - GPR30 antagonist
CBNumber:
CB32518797
분자식:
C19H16BrNO2
포뮬러 무게:
370.24
MOL 파일:
1161002-05-6.mol

(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline 속성

녹는점
178-180 °C
끓는 점
462.7±45.0 °C(Predicted)
밀도
1.472±0.06 g/cm3(Predicted)
저장 조건
Store at -20°C
용해도
insoluble in H2O; insoluble in EtOH; ≥37 mg/mL in DMSO
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
3.98±0.40(Predicted)
색상
White to off-white

안전

(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline C화학적 특성, 용도, 생산

개요

G protein-coupled estrogen receptor (GPER), or GPR30, specifically binds natural and man-made estrogens. It is thought to be involved in estrogen-sensitive cancers. GPER knockout mice are fertile, although they exhibit thymic atrophy, impaired glucose tolerance, and altered bone growth. G-15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM). It displays low affinity cross-reactivity with the classical estrogen receptor (ER), ERα, so that at doses greater than 1 μM it is capable of mediating limited ER-dependent transcriptional activity. G-15 antagonizes the anti-depressive effects of estrogen in vivo.

용도

(3aS,4R,9bR)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline is also known as “G-15”, a G-protein-coupled estrogen receptor antagonist designed for the treatment of estrogen-sensitive cancers.

(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline 준비 용품 및 원자재

원자재

준비 용품

(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline 공급 업체

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(3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline 관련 검색:

rHuBDNF Recombinant Mouse Leptin Z-PHE-BETANA rHuGlucagon Recombinant Human Stem Cell Factor, Sf9 HEPATITIS B SURFACE ANTIGEN, RECOMBINANT DEFEROXAMINE MESYLATE Bromocriptine mesylate D-Luciferin potassium salt Recombinant Streptavidin Epidermal Growth Factor rrVEGF RECOMBINANT HUMAN PROCALCITONIN PHORBOL 12-MYRISTATE 13-ACETATE Human alpha Fetoprotein Oxytocin HUPTH Silver
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