HPI-1 Hydrate

HPI-1 Hydrate Struktur
1262770-72-8
CAS-Nr.
1262770-72-8
Englisch Name:
HPI-1 Hydrate
Synonyma:
HPI-1 Hydrate;1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-Methoxyphenyl)-2-Methyl-5-oxo-3-quinolinecarboxylic Acid 2-Methoxyethyl Ester Hydrate
CBNumber:
CB42545196
Summenformel:
C27H31NO7
Molgewicht:
481.53754
MOL-Datei:
1262770-72-8.mol

HPI-1 Hydrate Eigenschaften

Sicherheit

HPI-1 Hydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50 = 1.5 μM) without significantly affecting Wnt signaling (IC50 ≥ 30 μM). HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor. HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.

Verwenden

HPI-1 is a Hedgehog pathway inhibitor; Gli1/Gli2 inhibitor.

HPI-1 Hydrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


HPI-1 Hydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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  • HPI-1 Hydrate
  • 1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-Methoxyphenyl)-2-Methyl-5-oxo-3-quinolinecarboxylic Acid 2-Methoxyethyl Ester Hydrate
  • 1262770-72-8
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