SCRIPTAID Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Scriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-
8 μM in a cell-
based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems. It induces cell cycle arrest in colon cancer cells in culture and inhibits tumor growth
in vitro and
in vivo. Scriptaid also facilitates the cloning of inbred mouse strains produced by somatic cell nuclear transfer.
Verwenden
Scriptaid has been used in post activation of oocytes and embryo culture.
Allgemeine Beschreibung
Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.
Biologische Aktivität
Novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.
SCRIPTAID Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
