Reversan

313397-13-6

CAS-Nr.: 313397-13-6

Englisch Name:: Reversan

Synonyma:: CBLC4H10;Reversan;Reversan, MRP1 and P-glycoprotein inhibitor;N-[3-(4-morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-(4-morpholinyl)propyl]-5,7-diphenyl-;5,7-Diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (3-morpholin-4-yl-propyl)-amide;ReversanQ: What is Reversan Q: What is the CAS Number of Reversan Q: What is the storage condition of Reversan Q: What are the applications of Reversan

CBNumber:: CB61883226

Summenformel:: C26H27N5O2

Molgewicht:: 441.52

MOL-Datei:: 313397-13-6.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 51

Reversan Eigenschaften

Schmelzpunkt:: 176-180°C

Dichte: 1.26±0.1 g/cm3(Predicted)

storage temp.: Store at RT

Löslichkeit: DMSO: ≥8mg/mL at ~60°C

pka: 11.33±0.46(Predicted)

Aggregatzustand: powder

Farbe: faint yellow to yellow

Sicherheit

WGK Germany	3

Reversan Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Reversan represents a new class of nontoxic MRP1 inhibitor, which may be clinically useful for the treatment of neuroblastoma.

Biologische Aktivität

Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin , vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo . Displays at activity on MRP2, MRP3, MRP5 and MRP5 transporters.

Reversan Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Reversan Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 51)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+86-18791163155 +86-13119157289	13119157289@163.com	China	2973	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94657	76
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32321	50
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8447	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	5933	55
Shanghai Chaolan Chemical Technology Center	021-QQ：65489617 15618227136	Sales@ATKchemical.com	China	7295	58

N-[3-(4-morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Reversan
CBLC4H10
5,7-Diphenyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (3-morpholin-4-yl-propyl)-amide
Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[3-(4-morpholinyl)propyl]-5,7-diphenyl-
ReversanQ: What is Reversan Q: What is the CAS Number of Reversan Q: What is the storage condition of Reversan Q: What are the applications of Reversan
Reversan, MRP1 and P-glycoprotein inhibitor
313397-13-6
C26H27N5O2
Aromatics
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals